An elegant microwave assisted one-pot synthesis of di(α-aminophosphonate) pesticides.

A new class of di(α-aminophosphonate) pesticides were prepared by the Kabachnik-Fields reaction under solvent- and catalyst-free conditions with microwave irradiation, and the products were obtained in good-to-excellent yields at shorter reaction time. These compounds were characterized by IR, (1)H, (13)C, (31)P NMR, and mass spectral data. Among them, compounds 4f, 4c, and 4h showed good pesticidal activity against Spodoptera litura, with 92.

One-step synthesis and bioassay of N-phosphoramidophosphonates.

A simple one-step synthesis was accomplished for the preparation of N-phosphoramidophosphonates by a direct reaction of phosphoramidate (1) with heterocyclic aldehydes (2a-j) and dialkyl phosphites at 60-70 degrees C in the presence of tetramethylguanidine. The tetramethylguanidine not only catalyses this reaction but also helps to form pure products in high yields in lesser time. They exhibited good insecticidal and antioxidant properties.