Bacterial cellulose (BC) stands out as a promising candidate for novel drug delivery systems due to its micro-mesoporous nanofibrous interconnected structure. However, its performance is limited by the burst release of hydrophilic drugs and lower incorporation of the less water-soluble or insoluble drugs. In this study, we explored its potential as a drug carrier for two distinct types of drugs: Diclofenac sodium and Simvastatin, representing water-soluble and water insoluble compounds, respectively.
View Article and Find Full Text PDFThe surge in microbial illnesses, notably seen during the COVID-19 pandemic, has led to the global use of face masks-cloth, surgical, medical, and respirator types-to curb respiratory pathogen spread. Widely used by the public, patients, and healthcare workers, masks play a key role in reducing airborne transmission. However, synthetic, non-biodegradable materials in these masks have sparked environmental concerns due to disposal issues.
View Article and Find Full Text PDFA novel avenue for advancing our understanding of kidney disease mechanisms and developing targeted therapeutics lies in overcoming the limitations of the existing models. Traditional animal models, while useful, do not fully capture the intricacies of human kidney physiology and pathophysiology. Tissue engineering offers a promising solution, yet current models often fall short in replicating the complex microarchitecture and biochemical milieu of the kidney.
View Article and Find Full Text PDFBone tissue engineering (BTE) is a multidisciplinary area that can solve the limitation of conventional grafting methods by developing viable and biocompatible bone replacements. The three essential components of BTE, i.e.
View Article and Find Full Text PDFDrug delivery and delivery systems are among the most important research disciplines today, and the relevance of nanofibers in achieving the appropriate release profile at specified sites for increased therapeutic advantages cannot be understated. Nanofiber-based drug delivery systems are fabricated and modified using a range of methods that entail a variety of factors and processes; tuning of these allows control of the drug release such as targeted, extended, multistage, and stimuli-responsive release. We explore nanofiber-based drug delivery systems from the most recent accessible literature, focusing on materials, techniques, modifications, drug release, applications, and challenges.
View Article and Find Full Text PDFThis study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator. The work also includes a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization. The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g at 1C.
View Article and Find Full Text PDFUnlabelled: The rapid spread of microorganisms such as bacteria, fungi, and viruses can be extremely detrimental and can lead to seasonal epidemics or even pandemic situations. In addition, these microorganisms may bring about fouling of food and essential materials resulting in substantial economic losses. Typically, the microorganisms get transmitted by their attachment and growth on various household and high contact surfaces such as doors, switches, currency.
View Article and Find Full Text PDFThe release of drug from bacterial cellulose (BC) is tuned to achieve immediate and controlled delivery by using two drying strategies: freeze-drying and oven-drying. Diclofenac sodium (DCF), a hydrophilic drug, was used as the model drug and was loaded in oven-dried BC (BC-OD-DCF) and freeze-dried BC (BC-FD-DCF) to obtain sustained release and burst release, respectively. BC dried by the two methods were characterized and found to possess different structures and morphologies.
View Article and Find Full Text PDFInt J Biol Macromol
July 2014
The organisation of poly-glucan chains into cellulose macromolecular microfibrils has been studied using small angle X-ray scattering (SAXS). Three kinds of cellulose - bacterial cellulose (BC), nata-de-coco (NdC) (food grade bacterial cellulose) and tunicate cellulose (TC) have been investigated. Given the large ambiguity in literature on the microfibril dimensions owing to different methods and data analysis strategies, a method to extract dimensions of cellulose microfibrils using SAXS has been shown, which was found to be consistent across all the samples.
View Article and Find Full Text PDFThe formation of a chiral-nematic phase from cellulose nanowhiskers has been frequently reported in the literature. The most popular theory used to explain the chiral interactions is that of twisted morphology of cellulose nanowhiskers. Two possible origins of twist have been suggested: the intrinsic chirality of cellulose chains and result of interaction of chiral surfaces.
View Article and Find Full Text PDF