The Antibacterial Efficacy of a Compound Extracted from Marine Sediment Bacterium Enterococcus Lactis (S-2): A Comparative Analysis Through In-Vitro and In-Silico Assessments.

Background: Marine sediment bacteria have been generating considerable attention lately due to their potential as valuable reservoirs of novel antimicrobial agents.

Aim: In vitro and in silico antibacterial activities of antibacterial compounds isolated from the marine sediment bacterium Enterococcus Lactis (S-2).

Methods: Coastal sediment samples were collected from Rameswaram, Ramnathapuram District, Tamil Nadu, India.

Fungal Diseases Caused by Serious Contamination of Pharmaceuticals and Medical Devices, and Rapid Fungal Detection Using Nano-Diagnostic Tools: A Critical Review.

Fungal-contaminated compounded pharmaceuticals and medical devices pose a public health problem. This review aimed to provide an organized overview of the literature on that critical issue. Firstly, it was found that compounding pharmacies can produce drugs that are contaminated with fungi, leading to outbreaks of severe fungal diseases.

Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice.

Background: The beneficial effects of statins, other than their hypocholesterolemia role, have been well documented, however, their use as an adjuvant drug with other antiseizure drugs, in the treatment of epilepsy is poorly understood.

Objective: This study aimed to investigate the symbiotic effect of ATOR along with either lacosamide (LACO) or levetiracetam (LEVE) on experimentally induced epilepsy (Maximal electro-shock-MES or pentylenetetrazol- PTZ) in mice models.

Methods: Conventional elevated-maze (EPM) and rotarod methods were performed to observe the behavioral effects.

Isolation and Identification of Bioactive Compounds with Antimicrobial Activity from Marine Facultative Anaerobe, .

Introduction: The marine ecosystem contains many microbial species that produce unique, biologically active secondary metabolites with complex chemical structures. We aimed to isolate and identify bioactive compounds with antimicrobial properties produced by a facultative anaerobic strain of Bacillus subtilis (AU-RM-1), isolated from marine sediment.

Methodology: We optimized the AU-RM-1 growth conditions, analyzed its growth kinetics and its phenotypic and genotypic characteristics.

Lectins Are the Sparkle of Hope for Combating Coronaviruses and the Global COVID-19.

Today the crisis of coronavirus disease 2019 (COVID-19) pandemic represents a threatworldwide because it is a leading cause of human morbidity and mortality. Besides, it possessesa destroying impact on countries' economies. Therefore, there is an urgent need for hardresearch work and global collaboration to find a potential therapy.

Mechanisms of Antimicrobial Resistance: Highlights on Current Advance Methods for Detection of Drug Resistance and Current Pipeline Antitubercular Agents.

Background: Sir Alexander Fleming accidentally discovered antibiotics in 1928. Antibiotics have played a significant role in treating infectious diseases. The extensive use of antibiotics has enabled the microorganisms to develop resistance against the antibiotics given, which has become a global concern.

A benzimidazole scaffold as a promising inhibitor against SARS-CoV-2.

The manuscript reports the green-chemical synthesis of a new diindole-substituted benzimidazole compound, B1 through a straightforward route in coupling between indolyl-3-carboxaldehyde and o-phenylenediamine in water medium under the aerobic condition at 75 ºC. The single crystal X-ray structural analysis of B1 suggests that the disubstituted benzimidazole compound crystallizes in a monoclinic system and the indole groups exist in a perpendicular fashion with respect to benzimidazole moiety. The SARS-CoV-2 screening activity has been studied against 1 × 10e4 VeroE6 cells in a dose-dependent manner following Hoechst 33342 and nucleocapsid staining activity with respect to remdesivir.

A hydrated 2,3-diaminophenazinium chloride as a promising building block against SARS-CoV-2.

Phenazine scaffolds are the versatile secondary metabolites of bacterial origin. It functions in the biological control of plant pathogens and contributes to the producing strains ecological fitness and pathogenicity. In the light of the excellent therapeutic properties of phenazine, we have synthesized a hydrated 2,3-diaminophenazinium chloride (DAPHCl·3HO) through direct catalytic oxidation of o-phenylenediamine with an iron(III) complex, [Fe(1,10-phenanthroline)Cl]NO in ethanol under aerobic condition.

Antifungal and antiovarian cancer properties of α FeO and α FeO/ZnO nanostructures synthesised by .

() infection shows a growing burden on human health, and it has become challenging to search for treatment. Therefore, this work focused on the antifungal activity, and cytotoxic effect of biosynthesised nanostructures on human ovarian tetracarcinoma cells PA1 and their corresponding mechanism of cell death. Herein, the authors fabricated advanced biosynthesis of uncoated α-FeO and coated α-FeO nanostructures by using the carbohydrate of .

Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Extract and Their Antimicrobial Activity.

Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper (BM) water extract for synthesizing iron oxide NPs and iron oxide/zinc oxide nanocomposite.

JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation.

Currently, available treatment for osteosarcoma is combinational chemotherapy of doxorubicin, cisplatin, and methotrexate before and after surgery with overall 5-year survival rate of less than 40%. The present study was aimed to assess the anticancer effects of a phytochemical named β-caryophyllene (BCP) in treating osteosarcoma. We assessed the effect of (BCP) on oxidative stress, proliferation, apoptosis, and inflammation in human bone cancer cells MG-63.