Ciprofloxacin and Azithromycin Antibiotics Interactions with Bilayer Ionic Surfactants: A Molecular Dynamics Study.

The introduction of pharmaceuticals into aquatic ecosystems can lead to the generation of antibiotic-resistant bacteria. This paper employed molecular dynamics simulations to examine the interactions between cationic/anionic surfactants and two antibiotics or drugs, namely, ciprofloxacin and azithromycin. The analysis focused on many factors to elucidate the mechanism by which the surfactant bilayer molecular structure affects the selected antibiotics.

Experimental and Simulation Investigation of an Adaptive Model Predictive Control Scheme: Model Parametrized by Orthonormal Basis Function.

The closed-loop system's performance in synthesizing model predictive control (MPC) heavily relies on the model used for prediction. In continuously operating plants, a linear model-based MPC is designed based on the operating point's linear model during the commissioning stage. However, if the plant requires significant transitions from its normal operating point, the linear model-based MPC may not be effective.