Optimizing non-invasive vagus nerve stimulation for treatment in stroke.

Stroke remains a leading cause of long-term disability worldwide. There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery. Transcutaneous vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic stroke.

Recurrent Cerebral Embolic Infarcts in a Patient With a Mechanical Valve: A Rare Case of Infective Endocarditis Caused by Parvimonas micra.

We present the case of a 60-year-old man with a history of mechanical mitral valve replacement and atrial fibrillation who developed infective endocarditis (IE) caused by (), resulting in recurrent cerebral infarctions. Despite increasing the intensity of anticoagulation therapy with warfarin and adding aspirin, the patient experienced four embolic cerebral infarctions. Following a single fever spike, blood cultures identified , although no other systemic features of IE were present.