Publications by authors named "Mubthasima Pp"
Article Synopsis
- Cervical cancer remains a significant health issue for women, with EPHA2 being overexpressed in this and other cancers, though its exact role in cervical cancer progression is not fully clear.
- This study explores how EPHA2 influences cervical cancer cell migration and immune response, showing that its knockdown reduces cell movement by affecting the CD113/Ezrin pathway and also impacts immune cell interactions via IL-6 signaling pathways.
- Additionally, the research finds that knocking down EPHA2 increases the effectiveness of the hormone 17β-Estradiol in inhibiting cancer cell proliferation and migration, indicating potential therapeutic avenues for cervical cancer.
Background: Cervical cancer ranks as the fourth most prevalent cancer among women globally, presenting a significant therapeutic challenge due to its resistance to cisplatin. Ephrin type-A receptor 2 (EPHA2) is prominently overexpressed in cervical cancer and plays a vital role in cisplatin resistance, although the underlying mechanisms remain incompletely elucidated. Mitochondrial dynamics, autophagy, and mitophagy are critical in mediating cisplatin resistance.
View Article and Find Full Text PDFThe Saccharomyces cerevisiae genome contains 6572 ORFs, of which 680 ORFs are classified as dubious ORFs. A dubious ORF is a small, noncoding, nonconserved ORF that overlaps with another ORF of the complementary strand. Our study characterizes a dubious/nondubious ORF pair, YPR099C/MRPL51, and shows the transcript and protein level expression of YPR099C.
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