Subregional hippocampal deformations in major depressive disorder.

Background: Hippocampal atrophy is a well reported feature of major depressive disorder, although the evidence has been mixed. The present study sought to examine hippocampal volume and subregional morphology in patients with major depressive disorder, who were all medication-free and in an acute depressive episode of moderate severity.

Methods: Structural magnetic resonance imaging scans were acquired in 37 patients (mean age 42 years) and 37 age, gender and IQ-matched healthy individuals.

Online resource for validation of brain segmentation methods.

One key issue that must be addressed during the development of image segmentation algorithms is the accuracy of the results they produce. Algorithm developers require this so they can see where methods need to be improved and see how new developments compare with existing ones. Users of algorithms also need to understand the characteristics of algorithms when they select and apply them to their neuroimaging analysis applications.

Construction of a 3D probabilistic atlas of human cortical structures.

We describe the construction of a digital brain atlas composed of data from manually delineated MRI data. A total of 56 structures were labeled in MRI of 40 healthy, normal volunteers. This labeling was performed according to a set of protocols developed for this project.