Publications by authors named "Muammer Osman Koksal"
Human pegivirus (HPgV) is transmitted through sexual or parenteral exposure and is common among patients receiving blood products. HPgV is associated with lower levels of human immunodeficiency virus (HIV) RNA and better survival among HIV-infected patients. This study aimed to investigate the prevalence of HPgV and determine its subtypes in HIV-infected individuals living in Istanbul, which has the highest rate of HIV infection in Türkiye.
View Article and Find Full Text PDFAmong sexually transmitted diseases, HIV causes very serious clinical manifestations that can lead to death. As a result, millions of people have to live with this problem that threatens their health. The virus attacks the immune system of the host, especially CD4+ T lymphocytes, causing the suppression of the immune system.
View Article and Find Full Text PDFArticle Synopsis
- * Using multiple real-time PCR methods to analyze DNA, the researchers identified infections in 68 patients, with Chlamydia trachomatis being the most prevalent (11.1%), followed by Neisseria gonorrhoeae (3.9%) and Mycoplasma genitalium (7.8%).
- * The findings highlighted that co-infections occurred in more than 20% of the cases, emphasizing the need for regular screening and advanced diagnostic techniques to improve treatment and prevention strategies for STDs.
Human papillomavirus (HPV)-associated tumors account for a significant proportion of head and neck squamous cell carcinomas (HNSCC) in developed countries. In recent years, there has been a rise of HPV infections associated with HNSCC, especially HPV16, which is the most commonly detected type in oral and oropharyngeal cancers. To investigate the frequency of HPV-driven HNSCC among patients living in Turkey, HPV DNA positivity and p16INK4A expression were assessed in primary tumor biopsies (n = 106).
View Article and Find Full Text PDFIntroduction: Co-receptors involved in cell entry of the human immunodeficiency virus (HIV) and mutations in genes encoding their ligands may play a role in the susceptibility to infection and resistance to the progression of the infection. The best studied mutations that can exist in these genes are the CCR5-Δ32, CCR2-64I and SDF1-3'A mutations. The frequency of these mutations vary from continent to continent and even from region to region.
View Article and Find Full Text PDFSyphilis seroprevalence among HIV-infected males in Istanbul, Turkey.
Rev Argent Microbiol
October 2021
Article Synopsis
- Syphilis is increasingly becoming a serious concern for HIV-infected individuals globally, with limited studies focusing on co-infection and reinfection in Istanbul, Turkey.
- In a study conducted from March to June 2018, 244 HIV-positive men were assessed, revealing a syphilis seroprevalence of 19.3%, with a notably higher rate of 28.7% among men who have sex with men (MSM).
- The findings highlight the urgent need for routine syphilis screening and education about sexually transmitted infections among HIV-infected patients, especially in high-prevalence areas like Turkey.
Article Synopsis
- Out of 419 urogenital swabs, 57 were found to be positive for the targeted infection, which is about 13.6%.
- Five genetic variants were identified, with genotype E being the most common at 36.4%, followed by G (23.6%), H (21.8%), D (16.4%), and F (1.8%), marking it as the first research on genital infection genotypes in symptomatic men in Istanbul, Turkey.
Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported cases of HIV infection.
View Article and Find Full Text PDFObjective: There is a well-known association between human papilloma virus (HPV) and cervical neoplasia. The aim of this study was to investigate the types of HPV DNA and to compare the results with colposcopic findings among women with abnormal cytology.
Material And Methods: A series of 76 consecutive women attending the clinic with the usual referral indications (ASC-US or higher in Pap) were examined by the conventional diagnostic tools (PAP smear, colposcopy,punch biopsy) and subjected to HPV testing.