Construction of I-RGDyC-PEG-PAMAM-DTX targeted drug delivery system and study of its physicochemical properties and biological activity.

Objective: To construct a novel targeted drug delivery nanoprobe: iodine-131-arginine-glycine-aspartate-tyrosine-cysteine peptide-polyethylene glycol-fifth generation polyamide-amine-docetaxel (I-RGDyC-PEG-PAMAM-DTX) and to investigate its physicochemical properties and biological activity.

Materials And Methods: Docetaxel was wrapped by solvent volatilization method, and the regression curve of DTX was constructed by high-performance liquid chromatography to determine its drug loading. The particle size of RGDyC-PEG-PAMAM-DTX was detected by dynamic light scattering.

Inhibitory effect of ketoconazole, quinidine and 1-aminobenzotriazole on pharmacokinetics of tetrahydropalmatine and its metabolite in rats.

tetrahydropalmatine (THP) is mainly metabolised by CYP450 enzymes.This study was to investigate the possible effect of co-administered CYP inhibitors on the pharmacokinetics of THP and its metabolites in rats.An established LC-MS/MS method has been applied for the evaluation of drug-drug interaction between THP and CYP inhibitors.

Neuroprotective Effects of (-)-Epigallocatechin-3-Gallate Against Focal Cerebral Ischemia/Reperfusion Injury in Rats Through Attenuation of Inflammation.

Stroke is the second leading cause of death among adults worldwide. (-)-Epigallocatechin-3-gallate (EGCG) has been demonstrated to exhibit neuroprotective functions in cerebral ischemia/reperfusion injury. However, the underlying mechanisms in this process and its contribution to the protection function remain unknown.

[Analyze on HPLC fingerprint of four main metropolis of herba pogostemonis].

Objective: To establish a method for analyzing HPLC fingerprint of Herba pogostemonis and compare the variability of four main producing areas.

Methods: Diamonsil (R) C18 column was used, the Methanol-0.1% phosphoric acid (gradient elution) as a mobile phase and detection wavelength was set at 254nm, column temperature was 25 degrees C and flow rate was 1.