[Inhibition of tissue factor by siRNA enhances doxorubicin-induced apoptosis in human neuroblastoma].

Objective: To investigate the regulation of tissue factor (TF) on doxorubicin-induced apoptosis in human neuroblastoma.

Method: The expression of TF was examined by Western blotting. TF siRNA-pSUPER plasmid was constructed by inserting a specific 19-nt silencing sequence targeting TF gene into pSUPER vector.

[Regulation of NF-kappaB/P65 by MDM2 in acute lymphoblastic leukemia in childhood].

Objective: MDM2 is considered a proto-oncogene due to its ability to inhibit P53 tumor-suppressor function. But, evidence showed that MDM2 might have a P53-independent role in tumorigenesis. MDM2 is over-expressed in human sarcoma and carcinoma.