Design and Synthesis of Novel Diphenyl Ether Carboxamide Derivatives To Control the Phytopathogenic Fungus .

Sclerotinia stem rot (SSR) caused by the phytopathogenic fungus has led to serious losses in the yields of oilseed rape and other crops every year. Here, we designed and synthesized a series of carboxamide derivatives containing a diphenyl ether skeleton by adopting the scaffold splicing strategy. From the results of the mycelium growth inhibition experiment, inhibition rates of compounds and showed more than 80% to control at a dose of 50 μg/mL, which is close to that of the positive control (flubeneteram, 95%).