Publications by authors named "Mu-Xiao Zhong"
Objective: To compare the risk factors associated with serrated polyps (SPs) and conventional adenoma (CA).
Methods: One hundred and three healthy control subjects, 100 patients with pathologically confirmed SPs and 115 with CA were randomly selected from individuals undergoing colonoscopy in Nanfang Hospital from 2012 to 2015. The demographic and clinical data were collected from the subjects, including age, gender, height, weight, hypertension, diabetes, smoking status, alcohol use, family history of colorectal cancer (CRC) and blood lipids.
[Expressions of inflammatory cytokines in intestinal mucosa and their prognostic value in patients with ulcerative colitis].
Nan Fang Yi Ke Da Xue Xue Bao
December 2016
Article Synopsis
- - The study aimed to analyze the expressions of cytokines IL-17, IL-23, IL-22, and IL-11 in the intestines of patients with ulcerative colitis (UC) to evaluate their prognostic significance.
- - Results showed that cytokine levels were notably higher in patients with active UC compared to those in remission and healthy controls, indicating a correlation between increased cytokine expression and disease severity.
- - The expressions of these cytokines were positively linked to both endoscopic and histological activity in UC patients, suggesting they could be useful biomarkers for assessing mucosal healing and disease prognosis.
Aim: To investigate the effect of GW4064 on the expression of adipokines and their receptors during differentiation of 3T3-L1 preadipocytes and in HepG2 cells.
Methods: The mRNA expression of farnesoid X receptor (FXR), peroxisome proliferator-activated receptor-gamma 2 (PPAR-γ2), adiponectin, leptin, resistin, adiponectin receptor 1 (AdipoR1), adiponectin receptor 2 (AdipoR2), and the long isoform of leptin receptor (OB-Rb) and protein levels of adiponectin, leptin, and resistin were determined using fluorescent real-time PCR and enzyme linked immunosorbent assay, respectively, on days 0, 2, 4, 6, and 8 during the differentiation of 3T3-L1 preadipocytes exposed to GW4064. Moreover, mRNA expression of AdipoR2 and OB-Rb was also examined using fluorescent real-time PCR at 0, 12, 24, and 48 h in HepG2 cells treated with GW4064.