Publications by authors named "Mu-Rong Liu"
Article Synopsis
- The study examined the relationship between CTRP1 levels in plasma and epicardial adipose tissue with congestive heart failure (CHF), highlighting its anti-inflammatory properties.
- Results showed that patients with CHF had higher CTRP1 levels compared to controls, and higher values at admission were linked to worse outcomes.
- CTRP1 was found to influence the release of aldosterone and IL-6, suggesting it plays a role in the development of CHF through specific signaling pathways.
Discussion about several potential drawbacks of PEGylated therapeutic proteins.
Biol Pharm Bull
October 2014
PEGylation changes the physical and chemical properties of the biomedical molecule, such as its conformation, electrostatic binding, and hydrophobicity, and results in an improvement in the pharmacokinetic behavior of the drug, while it also causes some disadvantages of which cannot be neglected. The available data manifests that polyethylene glycol (PEG) itself shows potential risk, such as immunogenicity of the PEG and PEG-containing vacuoles in cells observed with PEGylated biologicals. Decreased activity and heterogeneity are also the negative aspects of PEGylation.
View Article and Find Full Text PDF[Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats].
Zhong Xi Yi Jie He Xue Bao
November 2004
Objective: To evaluate the effects of madecassoside (MC) on the depression behavior of mice and the activities of monoamine oxidase (MAO) in different rat brain regions.
Methods: Imipramine as the positive contrast medicine, effects of MC on the depression behavior of mice were observed by forced swimming test and reserpine antagonist test. Moclobemide and pargyline as the positive controlled medicines, the activities of monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B) in different rat brain regions were determined after intragastric administration of MC in 3 different dosages for 3 days or 21 days.