Publications by authors named "Mu-Lie Chen"
Clin Sci (Lond)
March 2011
Article Synopsis
- The study investigates how postconditioning (postcon) protects the heart from damage after an acute myocardial infarction (AMI) by lowering levels of peroxynitrite (ONOO-) and reducing oxidative stress caused by inducible nitric oxide synthase (iNOS).
- In clinical trials on AMI patients, postcon was shown to decrease iNOS activity and plasma nitrotyrosine levels, leading to improved heart function compared to control subjects.
- Animal experiments confirmed these findings, showing that postcon lowered both iNOS activity and myocardial infarct size, while using an iNOS inhibitor mimicked postcon's effects, and an ONOO- donor negated its benefits, indicating that the cardioprotective mechanism involves
