Characterization of a novel Hoxa5eGFP mouse line.

Background: Hox genes encode transcription factors that are important for establishing the body plan. Hoxa5 is a member of the mammalian Hox5 paralogous group that regulates the patterning and morphology of the cervical-thoracic region of the axial skeleton. Hoxa5 also plays crucial functions in lung morphogenesis.

The Lung Elastin Matrix Undergoes Rapid Degradation Upon Adult Loss of Function.

genes encode transcription factors that are critical for embryonic skeletal patterning and organogenesis. The , , and paralogs are expressed in the lung mesenchyme and function redundantly during embryonic lung development. Conditional loss-of-function of these genes during postnatal stages leads to severe defects in alveologenesis, specifically in the generation of the elastin network, and animals display bronchopulmonary dysplasia (BPD) or BPD-like phenotype.