Publications by authors named "Mu-Feng Gu"
Background: This study aimed to investigate the dose-response association between alcohol consumption and atrial fibrillation (AF) risk.
Methods: PubMed, Embase, Cochrane Library, and Web of Science were systematically searched using keywords related to alcohol and AF from the establishment of databases up to 1 March 2021. Prospective studies examining the impact of alcohol on the risk of AF with hazard ratios (HRs) were included.
Article Synopsis
- The study investigates the role of BTBD7_hsa_circ_0000563, a circular RNA located on chromosome 14, in relation to atherosclerosis and identifies proteins regulated by its expression in coronary artery segments.
- Using RT-qPCR to measure expression levels and proteomic analysis to examine protein differences, the research found lower BTBD7_hsa_circ_0000563 levels in severely narrowed arteries and identified 49 proteins with significant expression changes correlated with its levels.
- The findings suggest that BTBD7_hsa_circ_0000563 may play a critical role in atherosclerotic changes, prompting the need for further studies to clarify its mechanisms and functions.
Article Synopsis
- Circular RNAs (circRNAs) are stable molecules that could serve as biomarkers and treatment targets for coronary artery disease due to their role in gene regulation.
- The study involved analyzing circRNAs from the coronary arteries of an 81-year-old man who died from a heart attack, revealing a total of 1,259 known and 381 new circRNAs through RNA sequencing.
- The research identified 66 circRNAs that were significantly regulated based on the presence of atherosclerosis, suggesting their potential involvement in the disease and their applicability in diagnostics or treatment.