Application of topical gentamicin-a new era in the treatment of genodermatosis.

Background: The clinical use of gentamicin always lies in its antimicrobial activity in the past as an aminoglycoside antibiotic. However, in the past decade, there were considerable interests in therapeutic approaches in treating hereditary diseases. Some of the genodermatosis is caused by nonsense mutations that create premature termination codons and lead to the production of truncated or non-functional proteins.

Pediatric dermatology-Critical approach to the new treatments.

The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology.

Skin Ceramide Profile in Children With Atopic Dermatitis.

Background: Atopic dermatitis (AD) is a common disease, which involves a disruption of the skin barrier function. Skin ceramide (CER) composition, which plays crucial roles in maintaining the barrier function of the stratum corneum, is changed in patients with AD.

Objective: The aim of this study was to identify and quantify skin CER subclasses in association with disease severity in pediatric patients with AD.