Numerical testing method and mechanical property evaluation of large particle size asphalt mixture.

The large particle size asphalt mixture with nominal maximum aggregate size 53 mm(LSAM-50) has good technical and economic performance and will become an effective technical way to build a full-thick long-life asphalt pavement with Chinese characteristics. In order to reveal the mechanical properties and influencing factors of LSAM-50 in depth, a numerical test method for the mechanical properties of the large particle size LSAM-50 asphalt mixture was developed, and a reasonable specimen size for LSAM-50 performance test was proposed by combining the numerical test and the indoor test. The results show that: LSAM-50 numerical test conditions are the calculation time step 10-3 s/step, the loading rate is 2 mm/min (uniaxial compression numerical test) and 50 mm/min (splitting numerical test) when LSAM-50 numerical experiment calculation rate and numerical experiment accuracy are better; after the size of the specimen reaches 200×160mm, the influence of the size effect is eliminated.

Kurtosis Assessment of Cardiovascular Disease Risk Caused by Complex Noise in Coal Mines.

Objectives: This study aims to investigate the relationship between noise kurtosis and cardiovascular disease (CVD) risk while exploring the potential of kurtosis assessment in evaluating CVD risk associated with complex noise exposure in coal mines.

Methods: This cross-sectional study started in April 2021 and ended in November 2022. It involved 705 coal miners selected from 1045 participants.

Genome-Wide Analysis Reveals Key Genes and MicroRNAs Related to Pathogenic Mechanism in .

is a parasite transmitted by mosquitoes and can cause a neglected tropical disease called Lymphatic filariasis. However, the genome of was not well studied, making novel drug development difficult. This study aims to identify microRNA, annotate protein function, and explore the pathogenic mechanism of by genome-wide analysis.

First Report of Causing Anthracnose on in China.

Vicia amoena is renowned for its high protein content and nutritional value, making it significant in animal production and traditional Chinese medicine production. In July 2023, typical anthracnose symptoms were observed on V. amoena leaves in Suihua City (125°82'E, 46°22'N), Heilongjiang Province, China, affecting approximately 40% of the plants (a total of 200 plants were surveyed).

Skin Microbiota, Circulating Metabolic Biomarker, Epilepsy: A Mendelian Randomization Analysis.

Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures. Currently, the associations among skin microbiota, circulating metabolites, and epilepsy are still not well studied. In this study, we applied univariate and two-step Mendelian randomization analysis using single nucleotide polymorphisms as instrumental variables to analyze the possible associations.

Harnessing nanoengineered CAR-T cell strategies to advance solid tumor immunotherapy.

The efficacy and safety of chimeric antigen receptor (CAR) T cell therapy is still inconclusive in solid tumor treatment. Recently, nanotechnology has emerged as a potent strategy to reshape CAR-T cell therapy with promising outcomes. This review aims to discuss the significant potential of nano-engineered CAR-T cell therapy in addressing existing challenges, including CAR-T cell engineering evolution, tumor microenvironment (TME) modulation, and precise CAR-T cell therapy (precise targeting, monitoring, and activation), under the main consideration of clinical translation.

Intermittent social isolation enhances social investigation but impairs social memory in adult male mice.

Social isolation profoundly impacts motivated behavior and neural plasticity. While the effects of acute and chronic social isolation have been extensively studied, the consequences of intermittent isolation during adulthood, particularly relevant to modern lifestyles, remain poorly understood. This study investigated the impact of intermittent social isolation (ISI) on social behavior and brain activation in adult male mice.

Development of a colloidal gold immunochromatographic strip for the rapid on-site detection of Ecytonucleospora hepatopenaei (EHP).

The Pacific white shrimp (Penaeus vannamei), one of the world's most economically important aquatic species, is highly susceptible to Ecytonucleospora hepatopenaei (EHP), a pathogen that infects the hepatopancreas and causes hepatopancreatic microsporidiosis (HPM), leading to stunted growth and substantial economic losses in shrimp farming. Currently, no effective treatments for EHP exist, making rapid on-site detection and preventive measures essential for disease control. While nucleic acid-based detection methods are commonly employed, they require specialized equipment, controlled environments, and trained personnel, which increase costs.

Y01 reduces HFD-induced obesity altering gut microbiota and metabolomic profiles and modulating adipose tissue macrophage M1/M2 polarization.

Obesity-related metabolic syndrome is intimately associated with infiltrated adipose tissue macrophages (ATMs), gut microbiota, and metabolic disorders. holds the potential to mitigate obesity; however, there exist strain-specific functionalities and diverse mechanisms, which deserve extensive exploration. This study aims to explore the potential of Y01, isolated from traditional sour whey, in alleviating HFD-induced metabolic syndrome in mice and elucidating its underlying mechanism.

Comparative study of trastuzumab modification analysis using mono/multi-epitope affinity technology with LC-QTOF-MS.

Dynamic tracking analysis of monoclonal antibodies (mAbs) biotransformation is crucial, as certain modifications could inactivate the protein and reduce drug efficacy. However, a particular challenge (i.e.

Development and Road Performance Verification of Aggregate Gradation for Large Stone Asphalt Mixture.

The pavement base and subbase are the main load-bearing structures of asphalt pavement, and their materials need to have sufficient bearing capacity. Therefore, in the development of LSAM-50 mixtures with higher bearing capacity, after significant research and engineering practice, conventional particle size asphalt mixtures have formed their own excellent mineral gradation and have been incorporated into relevant specifications, while LSAM-50 mixtures, including mineral gradation, have not been involved in related research and engineering applications. According to the strength composition mechanism of asphalt mixtures, under the same circumstances of asphalt, due to the large nominal maximum particle size of LSAM-50 and the small amount of asphalt used, the strength of mineral grading is more important than that of asphalt, which is one of the key issues to be solved in the research of LSAM-50 mixtures.

Customized Sized Manganese Sulfide Nanospheres as Efficient T MRI Contrast Agents for Enhanced Tumor Theranostics.

The impact of nanoparticle size on the effectiveness of magnetic resonance imaging (MRI) using sulfurized manganese nanoparticles (MnS@PAA) stabilized with polyacrylic acid (PAA) as a binder was thoroughly investigated. MnS@PAA nanoparticles of varying sizes were synthesized by altering the ratio of ethylene glycol (EG) to diethylene glycol (DEG) during the synthesis process. These nanoparticles exhibited a uniform size distribution and demonstrated high T relaxation rates, along with a notable pH-responsive behavior.

Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons.

Restricted and repetitive behavior (RRB) is a primary symptom of autism spectrum disorder (ASD), which poses a significant risk to individuals' health and is becoming increasingly prevalent. However, the specific cellular and neural circuit mechanisms underlying the generation of RRB remain unclear. In this study, it is reported that the absence of the ASD-related protein Neuroligin 1 (NLGN1) in dopamine receptor D2-expressing medium spiny neurons (D2-MSNs) in the dorsal striatum is associated with the duration and frequency of self-grooming and digging behaviors.

The discussion of the relationship between cardiopulmonary bypass and postoperative thyroid function changes in pediatric congenital heart disease, and the analysis of oral thyroid hormone therapy and cardiac prognosis.

Objective: This study aims to investigate the relationship between CPB factors and changes in TH levels in postoperative patients and the effect of oral levothyroxine sodium tablets on outcomes in patients with postoperative TF abnormalities.

Methods: Select patients who underwent CHD surgery between September 2017 and September 2023 and were aged 13 years or younger. The relationship between CPB and postoperative TF changes and the influencing factors were analyzed.

Integrated multi-omics analysis of the microbial profile characteristics associated with pulmonary arterial hypertension in congenital heart disease.

Dysregulation of immune and inflammatory cells around blood vessels and metabolic dysfunction are key mechanisms in the development of pulmonary arterial hypertension (PAH). The homeostasis of the human microbiome plays a crucial role in regulating immune responses and the progression of diseases. For pulmonary arterial hypertension associated with congenital heart disease involving body-lung shunt (PAH-CHD), the potential impact of the microbiome on the "gut-lung axis" remains underexplored.

Radiation-activated PD-L1 aptamer-functionalized nanoradiosensitizer to potentiate antitumor immunity in combined radioimmunotherapy and photothermal therapy.

Reactive oxygen species (ROS)-mediated immunogenic cell death (ICD) is crucial in radioimmunotherapy by boosting innate antitumor immunity. However, the hypoxic tumor microenvironment (TME) often impedes ROS production, limiting the efficacy of radiotherapy. To tackle this challenge, a combination therapy involving radiotherapy and immune checkpoint blockade (ICB) with anti-programmed death-ligand 1 (PD-L1) has been explored to enhance antitumor effects and reprogram the immunosuppressive TME.

Systemic delivery of tannic acid-ferric-masked oncolytic adenovirus reprograms tumor microenvironment for improved therapeutic efficacy in glioblastoma.

Glioblastoma (GBM) represents the most aggressive primary brain tumor, and urgently requires effective treatments. Oncolytic adenovirus (OA) shows promise as a potential candidate for clinical antitumor therapy, including in the treatment of GBM. Nevertheless, the systemic delivery of OA continues to face challenges, leading to significantly compromised antitumor efficacy.

Clinical significance of the modified Naples prognostic score in patients with stage II-III colon cancer undergoing curative resection: a retrospective study from the real world.

Background: The Naples prognostic score (NPS) determined by the nutritional and inflammatory condition of an individual is attracting growing attention for predicting postoperative outcomes in a variety of malignancies. The study aimed to assess the clinical significance of a modified NPS (M-NPS) and establish and validate nomograms incorporating M-NPS in curative stage II-III colon cancer patients.

Methods: We retrospectively analyzed 328 stage II-III colon cancer patients receiving radical surgical resection at our hospital from January 2011 to December 2016.