The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth.

The expression and biological function of the mitochondrial inner membrane protease YME1L (YME1 Like 1 ATPase) in NSCLC are tested here. Bioinformatical analyses and results from local human tissues show that YME1L expression is elevated in NSCLC tissues. YME1L upregulation was observed in primary and immortalized NSCLC cells.

Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing.

Diabetic chronic wound healing still faces huge clinical challenge. The arrangement and coordination of healing processes are disordered in diabetic wound caused by the persistent inflammatory response, microbial infection, impaired angiogenesis, resulting in the delayed and even non-healing wounds. Here, the dual-drug loaded nanocomposite polysaccharide-based self-healing hydrogels (OCM@P) with multifunctionality were developed to promote diabetic wound healing.

First-in-human evaluation of a novel ultrathin sirolimus-eluting iron bioresorbable scaffold: 3-year outcomes of the IBS-FIM trial.

Background: The first-generation polymeric bioresorbable scaffolds resulted in higher than acceptable 3-year rates of device-related adverse outcomes.

Aims: We aimed to assess the intermediate-term safety and performance of a novel ultrathin-strut sirolimus-eluting iron bioresorbable scaffold (IBS) in non-complex coronary lesions.

Methods: The prospective, single-arm, open-label IBS first-in-human study enrolled 45 patients, each with a single de novo lesion.

Enhanced Proliferation of Visualizable Mesenchymal Stem Cell-Platelet Hybrid Cell for Versatile Intracerebral Hemorrhage Treatment.

The intrinsic features and functions of platelets and mesenchymal stem cells (MSCs) indicate their great potential in the treatment of intracerebral hemorrhage (ICH). However, neither of them can completely overcome ICH because of the stealth process and the complex pathology of ICH. Here, we fabricate hybrid cells for versatile and highly efficient ICH therapy by fusing MSCs with platelets and loading with lysophosphatidic acid-modified PbS quantum dots (LPA-QDs).

A nonsense mutation in the CUL3 gene in a Chinese patient with autism spectrum disorder and epilepsy: A case report.

Rationale: CUL3 (OMIM: 603136) encodes cullin-3, a core component of ubiquitin E3 ligase. Existing medical research suggests that CUL3 mutations are closely related to neurodevelopmental disorder with or without autism or seizures (neurodevelopmental disorder with autism and seizures, OMIM: 619239). However, the number of published case reports of autism spectrum disorder due to CUL3 gene mutations is limited.

Generalized-Type Multistability of Almost Periodic Solutions for Memristive Cohen-Grossberg Neural Networks.

This article investigates a generalized type of multistability about almost periodic solutions for memristive Cohen-Grossberg neural networks (MCGNNs). As the inevitable disturbances in biological neurons, almost periodic solutions are more common in nature than equilibrium points (EPs). They are also generalizations of EPs in mathematics.

Relaxin-encapsulated polymeric metformin nanoparticles remodel tumor immune microenvironment by reducing CAFs for efficient triple-negative breast cancer immunotherapy.

Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cells in the tumor microenvironment which mediate desmoplastic response and are the primary driver for an immunosuppressive microenvironment, leading to the failure of triple-negative breast cancer (TNBC) immunotherapy. Therefore, depleting CAFs may enhance the effect of immunotherapy (such as PD-L1 antibody). Relaxin (RLN) has been demonstrated to significantly improve transforming growth factor-β (TGF-β) induced CAFs activation and tumor immunosuppressive microenvironment.

Physical activity-induced alterations of the gut microbiota are BMI dependent.

Physical inactivity is one of the leading causes of chronic metabolic disease including obesity. Increasing physical activity (PA) has been shown to improve cardiometabolic and musculoskeletal health and to be associated with a distinct gut microbiota composition in trained athletes. However, the impact of PA on the gut microbiota is inconclusive for individuals performing PA in their day-to-day life.

The forkhead box O3 (FOXO3): a key player in the regulation of ischemia and reperfusion injury.

Forkhead box O3 is a protein encoded by the FOXO3 gene expressed throughout the body. FOXO3 could play a crucial role in longevity and many other pathologies, such as Alzheimer's disease, glioblastoma, and stroke. This study is a comprehensive review of the expression of FOXO3 under ischemia and reperfusion (IR) and the molecular mechanisms of its regulation and function.

Rise and metabolic roles of during the fermentation of crab paste.

Microbial community may systematically promote the development of fermentation process of foods. Traditional fermentation is a spontaneous natural process that determines a unique nutritional characteristic of crab paste of , However, rare information is available regarding the development pattern and metabolic role of bacterial community during the fermentation of crab paste. Here, using a 16S rRNA gene amplicon sequencing technology, we investigated dynamics of bacterial community and its relationship with metabolites during the fermentation of crab paste.

Effects of hollow fiber packing density and housing shape on the albumin filtration performance of CRRT filters.

Continuous renal replacement therapy (CRRT) has become the most commonly used acute blood purification therapy for critically ill patients. As a key point of extracorporeal blood circulation, the CRRT filter plays a decisive role in therapeutic efficacy. However, few in vitro studies have been conducted on CRRT filters, particularly concerning the effects of design factors on filter effectiveness and safety profile; no comprehensive evaluation system has been established.

Hydrogen sulfide and its donors for the treatment of cerebral ischaemia-reperfusion injury: A comprehensive review.

As an endogenous gas signalling molecule, hydrogen sulfide (HS) is frequently present in a variety of mammals and plays a significant role in the cardiovascular and nervous systems. Reactive oxygen species (ROS) are produced in large quantities as a result of cerebral ischaemia-reperfusion, which is a very serious class of cerebrovascular diseases. ROS cause oxidative stress and induce specific gene expression that results in apoptosis.

Optimization of Sperm Cryopreservation Formulation in .

is a very important marine economic species, and its aquaculture industry has been developing rapidly. However, the phenomenon of marine wild capture of and germplasm degradation has become increasingly serious. It is necessary to develop the artificial farming industry and carry out germplasm resource protection, for which sperm cryopreservation technology is an effective method.

Stabilization and pattern formation in chemotaxis models with acceleration and logistic source.

We consider the following chemotaxis-growth system with an acceleration assumption, \begin{align*} \begin{cases} u_t= \Delta u -\nabla \cdot\left(u \bw \right)+\gamma\xkh{u-u^\alpha}, & x\in\Omega,\ t>0,\\ v_t=\Delta v- v+u, & x\in\Omega,\ t>0,\\ \bw_t= \Delta \bw -\bw +\chi\nabla v, & x\in\Omega,\ t>0, \end{cases} \end{align*} under the homogeneous Neumann boundary condition for $u,v$ and the homogeneous Dirichlet boundary condition for $\bw$ in a smooth bounded domain $\Omega\subset\R^{n}$ ($n\geq1$) with given parameters $\chi>0$, $\gamma\geq0$ and $\alpha>1$. It is proved that for reasonable initial data with either $n\leq3$, $\gamma\geq0$, $\alpha>1$ or $n\geq4,\ \gamma>0,\ \alpha>\frac12+\frac n4$, the system admits global bounded solutions, which significantly differs from the classical chemotaxis model that may have blow-up solutions in two and three dimensions. For given $\gamma$ and $\alpha$, the obtained global bounded solutions are shown to convergence exponentially to the spatially homogeneous steady state $(m,m,\mathbf 0$) in the large time limit for appropriately small $\chi$, where $m=\frac1{|\Omega|}\jfo u_0(x)$ if $\gamma=0$ and $m=1$ if $\gamma>0$.

High-efficiency focusing and imaging by dielectric kinoform zone plate lenses with soft X-rays.

With fast advances in enhancing the focusing/imaging resolution of Fresnel zone plate lenses toward sub-10 nm, low diffraction efficiency in connection with their rectangular zone shape still remains a big issue in both soft and hard X-ray microscopy. In hard X-ray optics, encouraging progress has recently been reported in our earlier attempts of high focusing efficiency by 3D kinoform shaped metallic zone plates, formed by greyscale electron beam lithography. This paper addresses our efforts towards high focusing/imaging efficiency by developing a novel dielectric kinoform zone plate lens for soft X-rays.

High carbon emissions from thermokarst lakes and their determinants in the Tibet Plateau.

Thermokarst lakes are potentially important sources of methane (CH ) and carbon dioxide (CO ). However, considerable uncertainty exists regarding carbon emissions from thermokarst lakes owing to a limited understanding of their patterns and motivators. In this study, we measured CH and CO diffusive fluxes in 163 thermokarst lakes in the Qinghai-Tibet Plateau (QTP) over 3 years from May to October.

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function.

Ectopic lipid deposition and mitochondrial dysfunction are common etiologies of obesity and metabolic disorders. Excessive dietary uptake of saturated fatty acids (SFAs) causes mitochondrial dysfunction and metabolic disorders, while unsaturated fatty acids (UFAs) counterbalance these detrimental effects. It remains elusive how SFAs and UFAs differentially signal toward mitochondria for mitochondrial performance.

Experiment Study on the Influence of Density and Confining Pressure on Triaxial Shear Properties of Calcareous Sand.

Calcareous sand is one of the main building materials in the construction of islands and reefs, and its shear property is very important for predicting their strength and deformation. However, the correlation research on the shear properties of calcareous sand is limited. In this paper, a series of the triaxial consolidation drainage shear tests of calcareous sand with relative densities (Dr) of 70% and 90% under confining pressures of 100, 200, 400 and 800 kPa were carried out by a triaxial testing apparatus, and the effects of relative density and confining pressure on the deformation and strength characteristics of calcareous sand were analyzed.

Adaptive changes of swimming crab (Portunus trituberculatus) associated bacteria helping host against dibutyl phthalate toxification.

The pollution of dibutyl phthalate (DBP) in aquatic environments is becoming an extensive environmental problem and detrimental to aquatic animals. Here, we quantified the response pattern of the bacterial community and metabolites of swimming crab (Portunus trituberculatus) juveniles exposed to 0.2, 2, and 10 mg/L DBP using 16 S rRNA gene amplicon sequencing coupled with metabolomic technique.

Detection of vertical root fractures by cone-beam computed tomography based on deep learning.

Objectives: This study aims to evaluate the performance of ResNet models in the detection of and vertical root fractures (VRF) in Cone-beam Computed Tomography (CBCT) images.

Methods: A CBCT image dataset consisting of 28 teeth (14 intact and 14 teeth with VRF, 1641 slices) from 14 patients, and another dataset containing 60 teeth (30 intact and 30 teeth with VRF, 3665 slices) from an model were used for the establishment of VRFconvolutional neural network (CNN) models. The most popular CNN architecture ResNet with different layers was fine-tuned for the detection of VRF.

Image quality comparison of lower extremity CTA between CT routine reconstruction algorithms and deep learning reconstruction.

Background: To evaluate the image quality of lower extremity computed tomography angiography (CTA) with deep learning-based reconstruction (DLR) compared to model-based iterative reconstruction (MBIR), hybrid-iterative reconstruction (HIR), and filtered back projection (FBP).

Methods: Fifty patients (38 males, average age 59.8 ± 19.

Causes and treatment strategies of unilateral leaflet escape of bileaflet mechanical prosthetic heart valves after surgery: a case series.

Background: During the eleven years from 2010 to 2021, preliminary statistics have shown that Fuwai Hospital completed 23,571 mechanical valve replacements for various types of valves, and 1139 mechanical valve replacements were performed in Guangyuan First People's Hospital. Only two patients developed valve leaflet escape, so valve leaflet escape is a rare postoperative complication.

Case Presentation: In 2010 and 2021, two patients were selected after they had unilateral leaflet escape after having mechanical valve replacements in Fuwai Hospital of Chinese Academy of Medical Sciences and Guangyuan First People's Hospital.