Publications by authors named "Mtambo T R"
The spread of SARS-CoV-2 has led to an interest in using ivermectin (a potent antiparasitic agent) as an antiviral agent despite the lack of convincing in vivo clinical data for its use against COVID-19. The off-target prophylactic use of ivermectin adds a substantial risk of drug-drug interactions with pharmaceutical medications used to treat chronic conditions like diabetes and hypertension (metformin and hydrochlorothiazide, respectively). Therefore, this study aims to evaluate the potential drug-drug interactions between ivermectin with either metformin or hydrochlorothiazide.
View Article and Find Full Text PDFHepatic Models to Assess Herb-Drug Interactions: Approaches and Challenges.
Pharmaceuticals (Basel)
March 2023
Article Synopsis
- There is growing awareness of the advantages of herbal treatments, but the production of these medications lacks standardized quality guidelines, which is essential for safety and efficacy.
- Despite their many therapeutic benefits, herbal medicines carry a risk of interactions with conventional drugs, necessitating thorough research to ensure safe usage.
- This review focuses on evaluating existing liver models that help understand the toxicity and pharmacological effects of herbal medicines, analyzing the strengths and weaknesses of these models from studies published between 1985 and December 2022.