Pre-sacral glomangioma: a rare localization of glomus tumors: case report.

Introduction And Importance: Deep-located glomangiomas are rarely reported. Because of their scarcity, treatment strategy is hard to establish. Herein, the authors report the first case to our knowledge of pre-sacral glomangioma.

Sigmoido-ovarian fistula complicating ovarian carcinosarcoma: a case report.

Introduction: Ovarian cancer is the leading cause of death from gynecological cancer. Ovarian carcinosarcomas represent a rare, aggressive entity with a poor prognosis. Spontaneous fistulization of ovarian cancer into the digestive tract is a rare phenomenon.

Intra-individual Dose Escalation of Abiraterone According to Its Plasma Exposure in Patients with Progressive Metastatic Castration-Resistant Prostate Cancer: Results of the OPTIMABI Trial.

Background And Objective: Trough abiraterone concentration (ABI C) of 8.4 ng/mL has been identified as an appropriate efficacy threshold in patients treated for metastatic castration-resistant prostate cancer (mCRPC). The aim of the phase II OPTIMABI study was to evaluate the efficacy of pharmacokinetics (PK)-guided dose escalation of abiraterone acetate (AA) in underexposed patients with mCRPC with early tumour progression.

Unraveling the role of the vitamin D-VDR pathway in pemphigus vulgaris from Tunisian patients.

Vitamin D dysregulation has been recognized as a factor that may cause or aggravate autoimmunity. Vitamin D deficiency was found to be common in pemphigus vulgaris (PV) in different populations. This study aimed to investigate the vitamin D-VDR pathway in PV in the Tunisian population.

The anti-Müllerian hormone: A useful tool for diagnosis of Polycystic Ovary Syndrome.

Background: Polycystic Ovary Syndrome (PCOS) is the most frequent endocrine disorder that affects reproductive-age women with important long-term health implications. As such, the anti-Müllerian hormone (AMH) was proposed as a helpful test to identify women with PCOS. The aim of this study was to determine an AMH cut-off value for the diagnosis of PCOS.

Characteristics of DRESS Syndrome in the Elderly: A Comparative Study of 55 Patients.

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare drug reaction characterized by a skin rash, eosinophilia, and organ involvement. Our purpose is to focus on the clinical and epidemiological characteristics of DRESS in the elderly and to identify the incriminated drugs. This is a retrospective study including patients, hospitalized for DRESS with a RegiSCAR ≥4.

Therapeutic Drug Monitoring of Tyrosine Kinase Inhibitors in the Treatment of Advanced Renal Cancer.

Seven tyrosine kinase inhibitor compounds with anti-angiogenic properties remain key drugs to treat advanced renal cell carcinoma. There is a strong rationale to develop therapeutic drug monitoring for these drugs. General considerations of such monitoring of the several groups of anticancer drugs are given, with a focus on oral therapy.

Gastrointestinal perforations by ingested foreign bodies: A preoperative diagnostic flowchart-based experience. A case series report.

Background: Gastrointestinal tract perforation is the most harmful complication of Foreign Body (FB) ingestion, besides diagnostic delay adversely affects the outcome. This paper aims to present our preoperative diagnostic flowchart and describe the surgical management in a Tunisian center.

Methods: A retrospective review of 48 patients with gastrointestinal perforation by ingested FB treated in the surgery department of Jendouba Hospital.

Efficacy of autologous platelet-rich plasma in the treatment of vitiligo: A 10-patient prospective study.

Introduction: Vitiligo is an autoimmune disorder characterized by loss of epidermal melanocytes. It has cosmetic and psychosocial impact. The objective of this paper is to evaluate the interest of platelet-rich-plasma in the treatment of vitiligo.

The management of appendicular abscesses in a Tunisian Tertiary Care Hospital.

Background: This study aims to describe the epidemiological, clinical, and radiological features of appendicular abscesses, compare the different approaches, and assess the safety and utility of laparoscopy in its management.

Methods: This descriptive retrospective study was carried out over 3 years extending from January 2017 to December 2019, reporting 150 appendicular abscesses cases. Data were collected from the register of the general surgery department B of the Rabta hospital.

Acute intraperitoneal rupture of hydatid cysts of the liver: Case series.

Hydatid cyst is a parasitic infection caused mainly by Echinococcus granulosus, which is generally considered benign. However, the hepatic hydatid cyst rupture in the abdominal cavity is a life-threatening incident that requires urgent and multidisciplinary management (emergency physicians, radiologists, anesthetists, and surgeons). This study describes clinical and paraclinical liver hydatid cyst rupture in the peritoneal cavity and details the appropriate treatment.

A rare case of prostate tuberculosis after holmium laser enucleation of the prostate.

Prostatic tuberculosis is considered to be a rare disease. It is usually associated with nonspecific symptoms and is detected incidentally after prostatic histological analysis. We report the case of a 60-year-old man suffering from acute urinary retention with an estimated 90 g prostate who underwent Holmium laser enucleation of the prostate.

46,XX male syndrome with mullerianosis of the urinary bladder: A new clinical entity.

Müllerianosis of the urinary bladder is a rare entity characterized by the presence of an admixture of at least two types of müllerian tissue in the muscularis propria of the bladder. We report the case of a 43-year-old male patient presented for urological evaluation due to episodes of total gross hematuria. Physical examination revealed ambiguous external genitalia.

Renal cell carcinoma in children, report of a new case.

Renal cell carcinoma (RCC) is rare in children and is usually found in late children. We present a case of a 14 year-old boy who presented with right lumbar pain. CT-scan showed a tumor in the upper pole of the right kidney measuring 15 cm.

Cystic renal oncocytoma: A rare case report.

Cystic renal lesions are extremely common. The major clinical concern is differentiating simple renal cysts from complex cysts to assess the risk of malignancy. The Bosniak classification of renal cystic tumors is employed to distinguish benign cysts from potential malignant cysts.

Gallbladder adenomyomatosis: Diagnosis and management.

Introduction: Gallbladder adenomyomatosis is a benign acquired gallbladder disease. It can mimic cancer on radiological findings, leading to a diagnostic dilemma. The management and prognosis of these two gallbladder anomalies are entirely different.

The deceitful diagnosis of gallbladder volvulus: A case report.

Introduction And Importance: The gallbladder volvulus is a rare but life-threatening condition characterized by an axial torsion of the gallbladder along the cystic pedicle, causing gallbladder ischemia and necrosis. This paper aims to present and discuss a rare case of gallbladder volvulus. This case report has been reported in line with the SCARE criteria 2020 [1].

Mitrofanoff external continent urinary diversion in the management of bladder exstrophy-epispadias complex in adolescents.

Despite theadvancements in surgical reconstructive techniques for bladder exstrophy-epispadias complex, urinary incontinence represents a major problem that affects the quality of life. Bladder augmentation associated to Mitrofanoff external continent urinary diversion (ECUD) constitute for some surgeon the best solution for the management of bladder exstrophyallowing to achieve continence and to preserve renal function.

Giant primary hydatid cyst of the adrenal gland: A rare case report.

Hydatid disease (HD) is a parasitic endemic zoononis in Tunisia, caused by the larval stage of Echinococcus Granulosus (EG). Adrenal glands are an uncommon and rare location for hydatid cysts, even in endemic areas, and primary adrenal cysts are exceptional. Herein, we report a rare case of 46-year-old man with primary giant adrenal hydatid cyst complicated by inferior vena cava thrombosis.

Intrarenal foreign body after PCNL procedure: A rare complication.

The use of LASER for lithotripsy has not only improved PCNL results, but also reported complications related to laser's use. We report a case of severed guide wire after PCNL.

[Urolithiasis of the kidney transplanted patient in south Tunisia: A 17-year experience].

Introduction: Urolithiasis in a kidney transplanted patient is an uncommon but complex urological complication. Its potential severity comes from its occurrence on a solitary kidney and on a field of immunosuppression. The aim of our study is to assess the incidence, characteristics and course of urolithiasis in our series.