Developing Hispolon-based novel anticancer therapeutics against human (NF-κβ) using approach of modelling, docking and protein dynamics.

Hispolon is a polyphenolic compound derived from black hoof mushroom () or shaggy bracket mushroom () which induces the inhibition of cancer-promoting nuclear factor-kappa beta (NF-κβ) complex. To develop more potent lead molecules with enhanced anticancer efficiency, the mechanism of hispolon-mediated nuclear factor-κβ inhibition has been investigated by molecular modelling and docking. Ten derivatives of hispolon (DRG1-10) have been developed by pharmacophore-based design with a view to enhance the anticancer efficacy.

Isolation and characterization of a thermophilic Bacillus sp. with protease activity isolated from hot spring of Tarabalo, Odisha, India.

Background And Objectives: Thermophilic bacteria are less studied but important group of microorganisms due to their ability to produce industrial enzymes.

Materials And Methods: In this study, thermophilic bacteria were isolated from hot spring of Tarabalo, India. A bacterium that could tolerate high temperatures was characterized by morphology, biochemistry and sequencing of its 16S rRNA gene.