Coumarin-carbazole based functionalized pyrazolines: synthesis, characterization, anticancer investigation and molecular docking.

A series of novel pyrazoline scaffolds from coumarin-carbazole chalcones were synthesized. We explored various acetyl, amide, and phenyl substituents at the -1 position of the pyrazoline core. The synthesized compounds were characterized by FTIR, H-NMR, C-NMR, DEPT, and mass spectroscopic techniques.

Implementation of Institutional Triaging Algorithms Decreases Head and Neck MDCT Use in Blunt Trauma.

Background Multidetector CT (MDCT) enables rapid and accurate diagnosis of head and neck (HN) injuries in patients with blunt trauma (BT). However, MDCT is overused, and appropriate selection of patients for imaging could improve workflow. Purpose To investigate the effect of implementing clinical triaging algorithms on use of MDCT in the HN in patients who have sustained BT.

A quality improvement project for reducing cardiac computed tomography radiation dose in a community-based, multihospital setting.

Radiation associated with computed tomography coronary angiography (CTCA) is a persistent concern. Strategies for reducing radiation exposure have been described, primarily in academic settings. We developed a standard protocol for CTCA acquisition focused on radiation reduction strategies in a community-based, multihospital setting and hypothesized that the protocol would be effective at reducing radiation in this setting.

The effect of tamoxifen or exemestane on bone mineral density during the first 2 years of adjuvant treatment of postmenopausal women with early breast cancer.

Background: Adjuvant therapy with aromatase inhibitors is associated with increased bone loss in postmenopausal women with breast cancer. We assessed changes in bone mineral density (BMD) from baseline to 24 months in patients receiving either tamoxifen (T) or exemestane (E).

Patients And Methods: A total of 578 women randomly assigned to T 20 mg per day orally or E 25 mg/day orally enrolled in this substudy; baseline, 12-month, and 24-month BMD measurements of the femur and lumbar spine by dual-energy x-ray absorptiometry were planned.

Age Associated Alterations in Structure and Function of the Cardiovascular System.

The process of aging leads to significant changes in the structure and function of the cardiovascular system. Some of these changes result directly in pathological effects, while others serve to exacerbate the effects of cardiovascular diseases. The changes in the walls of the peripheral arteries lead to increased systolic and pulse pressures.