Association of viable Mycobacterium leprae with Type 1 reaction in leprosy.

Unlabelled: The working hypothesis is that, viable Mycobacterium leprae (M. leprae) play a crucial role in the precipitation of Type 1 reaction (T1R) in leprosy.

Material And Methods: A total of 165 new multibacillary patients were studied.

Hypophosphorylation of NF-H and NF-M subunits of neurofilaments and the associated decrease in KSPXK kinase activity in the sciatic nerves of swiss white mice inoculated in the foot pad with mycobacterium leprae.

Objective: To study the phosphorylation state of neurofilament (NF) proteins and activity of KSPXK kinase in the sciatic nerves of Swiss white (S/W) mice inoculated in the hind foot pads with M. leprae.

Design: Test group includes S/W mice inoculated in the foot pads with freshly harvested human derived (viable) M.