The textures of sarcoidosis: quantifying lung disease through variograms.

. Sarcoidosis is a granulomatous disease affecting the lungs in over 90% of patients. Qualitative assessment of chest CT by radiologists is standard clinical practice and reliable quantification of disease from CT would support ongoing efforts to identify sarcoidosis phenotypes.

Sarcoidosis in Beryllium Exposed Workers: A Case-Case Study.

Background: Despite the utility of the beryllium lymphocyte proliferation test (BeLPT), distinguishing sarcoidosis, a disease of unknown etiology, from chronic beryllium disease (CBD), has long posed a diagnostic challenge. It is unclear if beryllium-exposed sarcoidosis cases (Be-exp-Sarc) are clinically distinct from CBD, or are misdiagnosed cases of CBD.

Methods: We performed a case-case study of 40 beryllium-exposed individuals diagnosed with Be-exp-Sarc compared to 40 frequency-matched CBD cases.

Does Online Social Support Affect the Eating Behaviors of Polish Women with Insulin Resistance?

Background: Insulin resistance, a key factor in developing type 2 diabetes mellitus, is linked to various health conditions. The basis of its treatment is lifestyle modification. However, adherence to nutritional and other medical recommendations can be challenging for chronic disease patients due to many factors, including demographics, social context, gender, age, and the patient's baseline health condition.

Multi-omic signatures of sarcoidosis and progression in bronchoalveolar lavage cells.

Background: Sarcoidosis is a heterogeneous granulomatous disease with no accurate biomarkers of disease progression. Therefore, we profiled and integrated the DNA methylome, mRNAs, and microRNAs to identify molecular changes associated with sarcoidosis and disease progression that might illuminate underlying mechanisms of disease and potential biomarkers.

Methods: Bronchoalveolar lavage cells from 64 sarcoidosis subjects and 16 healthy controls were used.

Metabolic profiling of single cells by exploiting NADH and FAD fluorescence via flow cytometry.

Objective: The metabolism of different cells within the same microenvironment can differ and dictate physiological or pathological adaptions. Current single-cell analysis methods of metabolism are not label-free.

Methods: The study introduces a label-free, live-cell analysis method assessing endogenous fluorescence of NAD(P)H and FAD in surface-stained cells by flow cytometry.

The textures of sarcoidosis: quantifying lung disease through variograms.

Objective: Sarcoidosis is a granulomatous disease affecting the lungs in over 90% of patients. Qualitative assessment of chest CT by radiologists is standard clinical practice and reliable quantification of disease from CT would support ongoing efforts to identify sarcoidosis phenotypes. Standard imaging feature engineering techniques such as radiomics suffer from extreme sensitivity to image acquisition and processing, potentially impeding generalizability of research to clinical populations.

Expediting online liquid chromatography for real-time monitoring of product attributes to advance process analytical technology in downstream processing of biopharmaceuticals.

The application of Process Analytical Technology (PAT) principles for manufacturing of biotherapeutics proffers the prospect of ensuring consistent product quality along with increased productivity as well as substantial cost and time savings. Although this paradigm shift from a traditional, rather rigid manufacturing model to a more scientific, risk-based approach has been advocated by health authorities for almost two decades, the practical implementation of PAT in the biopharmaceutical industry is still limited by the lack of fit-for-purpose analytical methods. In this regard, most of the proposed spectroscopic techniques are sufficiently fast but exhibit deficiencies in terms of selectivity and sensitivity, while well-established offline methods, such as (ultra-)high-performance liquid chromatography, are generally considered as too slow for this task.

The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles of .

Drying is an inseparable part of industrial microalgae production. In this work, the impacts of eight different drying methods on the metabolome and lipidome of were investigated. The studied drying methods were freeze drying (FD), sun drying (SD), air drying at 40 and 75 °C (AD' and AD″), infrared drying at 40 and 75 °C (IRD' and IRD″), and vacuum drying at 40 and 75 °C (VD' and VD″).

Stress and Coping Strategies among Women in Late Motherhood.

The shifting reproductive age of women is reflected in European populations. Pregnancy in women older than 35 years is considered high-risk and can be an additional source of stress. The aim of this study was to assess the perceived stress of women experiencing late motherhood and the coping strategies used.

Post-Chromatographic Derivatization Coupled with Mass Spectrometry as a Method of Profiling and Identification of Antioxidants; Phytocomplex as an Example.

High-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) coupled with radical scavenging assays, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) can be both used for the detection of the antioxidants in plant extracts. In this study, the ethanolic (70% /) extracts from different morphological parts of collected at different stages of maturity were used as the source of antioxidants. The final identification of antioxidants was performed using high-resolution mass spectroscopy (HRMS).

Phytochemical screening and biological evaluation of Greek sage (Salvia fruticosa Mill.) extracts.

This study explores the influence of extraction solvents on the composition and bioactivity of Salvia fruticosa extracts. Ultrasound-assisted extraction with water, ethanol and their mixtures in variable proportions was used to produce four different extracts. An untargeted UPLC/MS‑based metabolomics was performed to discover metabolites profile variation between the extracts.

Compartment-specific protein interactions in beryllium lung disease.

https://bit.ly/3PLNTXC.

Profiling orthorexia nervosa in young adults: the role of obsessive behaviour, perfectionism, and self-esteem.

Background: Orthorexia nervosa (ON) is a relatively new potential eating disorder characterized by an intense fixation on one's eating habits and the imposition of rigid and inflexible rules on oneself. Psychological factors such as obsessive-compulsive tendencies, perfectionism and self-esteem may interact in complex ways and contribute to the development and maintenance of ON.

Methods: This cross-sectional study included 977 participants from Italy, Lebanon, and Poland.

Study of the TIG Welding Process of Thin-Walled Components Made of 17-4 PH Steel in the Aspect of Weld Distortion Distribution.

This article presents the results of a study on the distribution of weld distortion in thin-walled components made of 17-4 PH steel, resulting from TIG (Tungsten Inert Gas) welding. Both manual and automatic welding processes were examined. Physical simulation of the automated welding process was conducted on a custom-built welding fixture.

New UNOS allocation system associated with no added benefit in waitlist outcomes and worse post-transplant survival in heart-kidney patients.

Background: The 2018 United Network for Organ Sharing (UNOS) heart transplant policy change (PC) sought to improve waitlist risk stratification to decrease waitlist mortality and promote geographically broader sharing for high-acuity patients awaiting heart transplantation. Our analysis sought to determine the effect of the UNOS PC on outcomes in patients waiting for, or who have received, a heart-kidney transplantation.

Methods: We analyzed adult (≥18 years old), first-time, heart-only and heart-kidney transplant candidates and recipients from the UNOS Registry.

Influence of Heat Treatment Parameters of Austempered Ductile Iron on the Microstructure, Corrosion and Tribological Properties.

The influence of heat treatment parameters such as the annealing time and austempering temperature on the microstructure, tribological properties and corrosion resistance of ductile iron have been investigated. It has been revealed that the scratch depth of cast iron samples increases with the extension of the isothermal annealing time (from 30 to 120 min) and the austempering temperature (from 280 °C to 430 °C), while the hardness value decreases. A low value of the scratch depth and a high hardness at low values of the austempering temperature and short isothermal annealing time is related to the presence of martensite.

Comparative Study on Assisted Solvent Extraction Techniques for the Extraction of Biologically Active Compounds from and .

The plants in the genus are postulated to exhibit several important medicinal properties due to their unique chemical composition. To isolate the targeted phytochemical compounds, the selection of a suitable extraction method is of primary importance. In this work, a comparative study on the phytochemical profiles of various and extracts has been carried out.

Identification of Factors Affecting Self-Efficacy in Women with Spontaneous Pregnancy Loss.

Pregnancy loss is a difficult situation that can affect a woman's physical and psychological health, and thus requires appropriate management and support. An individual's sense of self-efficacy is an important factor in the process of coping with a problem. Therefore, an analysis of self-efficacy in women after spontaneous pregnancy loss is warranted, so as to establish its association with social support, socio-demographic variables, quality of care, and specific behaviors of the medical staff.

Numerical and Physical Simulation of MAG Welding of Large S235JRC+N Steel Industrial Furnace Wall Panel.

This paper presents the results of a study on the development of a Metal active gas (MAG) welding technology for an industrial furnace component made of steel S235JRC+N with respect to the minimizationof welding deformation. A numerical simulation of the welding process was performed in the first phase of the research. The numerical simulation was carried out with the SYSWELD software.

Trait Anxiety and Unhealthy Eating in Adult Women: The Mediating Role of Cognitive Instability.

Unlabelled: Previous studies have demonstrated the influence of affective states on unhealthy eating. Heightened impulsivity has also been recognized as a risk factor for unhealthy eating. The objective of the present study was to investigate the relationship between trait anxiety and unhealthy eating and to test whether cognitive instability (trait impulsivity component) might mediate this relationship among adult women.

Calorimetric Method for the Testing of Thermal Coefficients of the TIG Process.

This paper presents an original design of a test apparatus for calorimetric measurements of arc efficiency η and melting efficiency η in welding processes. The construction and principle of operation of a new flow calorimeter are described, as well as the method for determining the η and η values in the process of the surface melting of aluminium-silicon alloy casting surfaces with a concentrated heat flux generated by the TIG (Tungsten Inert Gas) method. The results obtained indicate the advisability of using calorimetric testing to assess the arc efficiency of welding processes.

Nurses Coping with Stressful Situations-A Cross-Sectional Study.

Nursing belongs to the group of professions particularly exposed to stress. Since the ability to cope with stress is an important aspect of mental health, the aim of this study was to identify the types of nurses' behaviours in terms of different coping styles used when dealing with work-related and psychosocial stress. The study was conducted among 1223 Polish nurses by means of a diagnostic survey, using the Coping in Stressful Situations Questionnaire (CISS), the Generalised Self-Efficacy Scale (GSES) and a questionnaire of the author's own design.