The diagnostic value of G-CSF measurement in the sera of colorectal cancer and adenoma patients.

Background: Granulocyte-colony stimulating factor (G-CSF) regulates the growth of hematopoietic progenitor cells. Cancer cells, including colorectal cancer, can produce this cytokine. The aim of this study was to compare the diagnostic value of measurement of G-CSF and classic tumor markers--carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) in the sera of colorectal cancer with adenoma patients and to determine its usefulness in the diagnosis of colorectal cancer and polyps.

Pretreatment serum levels of hematopoietic cytokines in patients with colorectal adenomas and cancer.

Background And Aim: Hematopoietic cytokines (HCs) regulate the proliferation and differentiation of hematopoietic progenitor cells, and it was proved that HCs can promote cancer growth. The aim of this study is to determine whether HCs might be useful in the diagnosis of colorectal cancer.

Materials And Methods: We compared the serum levels of stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage colony-stimulating factor (M-CSF) in 97 colorectal cancer patients with those in 35 patients with colorectal adenomas and 65 healthy subjects (control group).

Stem cell factor (SCF) and interleukin 3 (IL-3) in the sera of patients with colorectal cancer.

For a long time markers that can detect a malignant cell transformation as early as possible have been sought. Substances which have been discovered are known as tumor markers. Stem cell factor (SCF) and interleukin 3 (IL-3) are members of a group of glycoprotein growth factors called hematopoietic cytokines (HCs).

[Plasma level of macrophage-colony stimulating factor (M-CSF) in the course of breast cancer treatment].

Macrophage-colony stimulating factor (M-CSF) is one of the glycoproteins called colony-stimulating factors (CSF). Some clinical investigations have shown an autologous production of M-CSF in various human cell lines in vitro and by tumour cells in vivo. We have investigated the plasma level of M-CSF and commonly accepted tumour marker, such as CA 15-3 in the plasma of 44 patients with breast cancer.

[Serum concentration of interleukin-12 (IL-12) in patients undergoing abdominal aortic aneurysm repair--preliminary report].

Abdominal aortic aneurysm surgery (AAA) is associated with perturbations of immune response and decreased immunity to infection, followed by high risk of organ and systemic complications development, including sepsis. The postoperative mortality in patients with AAA comes up to 10-12% and determines us to look for factors that may influence the immune response and are important for uneventful postoperative course. IL-12 is a potent immunoregulatory cytokine, that regulates cellular and humoral immunity.

Hematopoietic cytokines as tumor markers.

Stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-CSF) and macrophage-colony stimulating factor (M-CSF) are members of a group of glycoproteins called hematopoietic cytokines (HCs). These cytokines regulate the growth and differentiation of hematopoietic progenitor cells and functionally activate mature neutrophils or macrophages. The effect of HCs is not limited to bone marrow cells.

[Tumor markers of breast cancer].

The most frequent cancer amongst women is that of the breast. Tumor markers may be helpful in the early diagnosis of breast cancer and the initial assessment of the extent of disease, as well as in monitoring tumor growth or volume reduction, and a recurrence of cancer. They have also been used for monitoring the clinical course of chemotherapy and radiotherapy.

Serum concentrations of MCP-1 and RANTES in patients during aortic surgery: the relationship with ischemia-reperfusion.

Introduction: Surgical trauma is associated with depression of the immune system, which results in a high complication rate following abdominal aortic aneurysm (AAA) repair. Monocyte chemotactic protein-1 (MCP-1) and regulated-on-activation normal T cell expressed and secreted (RANTES) protein are important mediators of the immune and inflammatory response. The aim of this study was to determine whether there is any relationship between MCP-1 or RANTES and operative injury and ischemia-reperfusion during AAA surgery in human.

The importance of interleukin 18, glutathione peroxidase, and selenium concentration changes in acute pancreatitis.

Cytokinemia and oxidative stress are important factors responsible for an inadequate immune response in the early course of acute pancreatitis (AP). The aim of the study was to evaluate the profiles of interleukin 18 (IL-18), glutathione peroxidase (GPx), and selenium concentrations in serum with respect to AP severity and to study the relationships between these parameters and recognized prognostic indicators of AP severity. Prospective clinical analyses were performed on 61 patients with mild and severe forms of AP and for 15 healthy volunteers.

Homocysteine and progression of coronary artery disease.

Background: Hyperhomocysteinemia is one of the newly recognised risk factors of coronary artery disease (CAD). The role of hyperhomocysteinemia in the development of atherosclerosis has been controversial.

Aim: To assess homocysteine (Hcy) plasma concentration in patients with CAD and to correlate Hcy level with some cardiovascular risk factors.

[Granulocyte-colony stimulating factor (G-CSF) in the plasma and activity of enzymes in granulocytes of breast cancer patients].

Objectives: G-CSF is a stimulatory factor of granulocyte colony formation. In vitro and in vivo G-CSF stimulates the proliferation of granulocyte precursors and enhances phagocytic functions of mature cells. Indirect evidence of this might be the increase of the activity of granulocyte enzymes participating in phagocytosis.

Stem cell factor and macrophage-colony stimulating factor in patients with pancreatic cancer.

Stem cell factor (SCF) and macrophage-colony stimulating factor (M-CSF) have assumed an increasing importance in cancer biology. In the present study we investigated the serum levels of these cytokines in pancreatic cancer patients in relation to controls and to patients with benign lesions of the pancreas (chronic pancreatitis group). The classical tumor markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) were also tested.

[Stem cell factor (SCF) in clinical practice].

Stem cell factor (SCF) is a hematopoietic factor active in the early stages of hematopoiesis. Recognition of biological properties of SCF made a hope for its use in diagnosis and therapy of many diseases, especially neoplasmas. We present a characterization of SCF, its attempts to use in medicine and future possibilities of application.

[Selected hematopoietic cytokines in patients with colorectal cancer].

We have investigated the serum level of selected hematopoietic cytokines, such as interleukin 3, granulocyte-macrophage--colony stimulating factor (GM-CSF), granulocyte--colony stimulating factor (G-CSF) and macrophage--colony stimulating factor (M-CSF) in colorectal cancer patients. Also correlations between their concentrations and stages were made. The study was done on group consisted of 30 diagnosed colorectal cancer patients.

[Cytokines as tumor markers in breast cancer].

Serum tumour markers may be helpful in early diagnosis of breast cancer, in the initial assessment of the extent of the disease, and in monitoring of the tumor growth or tumor volume reduction. Recent studies have focused the role of cytokines as a new group of tumour markers for breast cancer.

[Macrophage colony-stimulating factor (M-CSF) as a candidate for the tumor marker of breast cancer].

Macrophage--colony stimulating factor (M-CSF) is one of the glycoproteins called colony-stimulating factors (CSFs). Some clinical investigations have shown autologous production of M-CSF various human cell lines in vitro and by tumors in vivo. We have investigated the plasma level of M-CSF and commonly accepted tumour markers, such as CA 15-3 in breast cancer.

Diagnostic value of pancreatic elastase-1 in human acute pancreatitis.

The diagnosis of acute pancreatitis (AP) is usually confirmed by a significant increase of the serum amylase and/or lipase level. However, serum pancreatic elastase-1 (pEla-1) was found to be a more sensitive diagnostic marker in AP, when assayed by the radioimmunoassay procedure. We analyzed the serum concentration of pEla-1, measured by the ELISA technique in 46 patients with AP and in a control group of 12 healthy volunteers.