Publications by authors named "Mrigendra K Rajput"
Bovine viral diarrhea virus (BVDV) has long been associated with a wide variety of clinical syndromes and immune dysregulation, many which result in secondary bacterial infections. Current understanding of immune cell interactions that result in activation and tolerance are explored in light of BVDV infection including: depletion of lymphocytes, effects on neutrophils, natural killer cells, and the role of receptors and cytokines. In addition, we review some new information on the effect of BVDV on immune development in the fetal liver, the role of resident macrophages, and greater implications for persistent infection.
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- Bovine viral diarrhea virus (BVDV) is an RNA virus that can cause persistent infections in calves when the mother is infected during a specific time in pregnancy.
- Noncytopathic (ncp) strains of BVDV can mutate into cytopathic (cp) strains, which are linked to fatal mucosal disease in persistently infected animals upon superinfection.
- A study of 136 cows revealed that 23 found to have persistent infections succumbed to mucosal disease, and the cp viruses isolated showed high genetic similarity, indicating a possible single origin of the infection in the herd.
Article Synopsis
- Dendritic cells are key players in the immune system, and the study focused on how bovine viral diarrhea virus (BVDV) affects their functions and ability to replicate.
- Four strains of BVDV were tested to see how they impacted the expression of crucial cell surface markers on monocyte-derived dendritic cells (Mo-DC), which are important for T cell activation.
- The results showed that Mo-DC lost their ability to produce infectious virus as they matured, while the non-cytopathic (ncp) strains reduced cell surface marker expression, contrasting with cytopathic (cp) strains that increased it.