Publications by authors named "Mridula K Venkateswaran"
Article Synopsis
- The study identifies the endoplasmic reticulum (ER) as a significant storage site for intracellular magnesium (Mg) and highlights the protein TMEM94 (ERMA) as a key player in its transport.* -
- TMEM94 is characterized as a multi-pass transmembrane protein with structural similarities to P-type ATPases, featuring unique domains for nucleotide and phosphorylation interactions.* -
- Research indicates that a specific tyrosine residue in TMEM94 is vital for Mg binding and function, with implications for cardiac health shown in both mice and human heart cells.*
The most abundant cellular divalent cations, Mg (mM) and Ca (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of magnitude affinity preference, but the physiological significance of this competition remains elusive. In mice consuming a Western diet, genetic ablation of the mitochondrial Mg channel Mrs2 prevents weight gain, enhances mitochondrial activity, decreases fat accumulation in the liver, and causes prominent browning of white adipose. Mrs2 deficiency restrains citrate efflux from the mitochondria, making it unavailable to support de novo lipogenesis.
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