Effects of SGLT-2 inhibitors on clinical and biological hyperandrogenism and menstruation irregularities in patients with polycystic ovary syndrome: A systematic review of randomized trials.

Introduction: Polycystic ovary syndrome is a common chronic condition characterized by insulin resistance and hyperandrogenism, leading to significant health risks and impaired quality of life. Sodium-glucose transporter type 2 inhibitors have shown promise in improving the metabolic profile of women with polycystic ovary syndrome. However, their impact on hormonal parameters and cycle disorders remains uncertain.

Impact of non-severe infections on cortisol and thyroid stimulating hormone baseline levels in hospitalized patients: A monocentric cross-sectional study.

The hormonal balance is dependent on the internal and external stimuli. The baseline cortisol (BC) and thyroid stimulating hormone (TSH) levels have been observed to vary and have a predictive value in critical illness settings. Few reports have studied their variation in non-severe acute illness.

Influence of barium substitution on the physical, thermal, optical and luminescence properties of Sm-doped metaphosphate glasses for reddish orange light applications.

Our present study focuses on examining the thermal, structural and luminescent characteristics of sodium barium metaphosphate glasses doped with Sm. Glass samples with molar compositions (100 - )[(50PO)-(50-NaO)-(BaO)]-SmO, where = 20, 25, 30, 35, 40 and = 0.3 and 1% were first synthesized by conventional melt quenching and later dehydroxylated under a constant N flow to ensure final glasses with a very high degree of chemical and optical homogeneity and free of water.

Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions.

Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik-Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution reaction of bis(α-aminophosphonates) prepared and ethyl (2-bromomethyl)acrylate under mild reaction conditions afforded an original synthetic approach to a new series of bis(allylic-α-aminophosphonates).

Beyond 5G Fronthaul Based on FSO Using Spread Spectrum Codes and Graphene Modulators.

High data rate coverage, security, and energy efficiency will play a key role in the continued performance scaling of next-generation mobile systems. Dense, small mobile cells based on a novel network architecture are part of the answer. Motivated by the recent mounting interest in free-space optical (FSO) technologies, this paper addresses a novel mobile fronthaul network architecture based on FSO, spread spectrum codes, and graphene modulators for the creation of dense small cells.

[Transient thickening of the pituitary stalk followed by a supra-pituitary Langerhansian histiocytosis : consequence or mere coincidence ?].

One of the difficult challenges in endocrinology is the etiological diagnosis of isolated thickened pituitary stalk (PS). We report the case of a woman in whom a thickened PS was diagnosed following the onset of central diabetes insipidus revealed by polyuria-polydypsia syndrome of late pregnancy and postpartum. The pituitary exploration showed panhypopituitarism with disconnecting hyperprolactinemia.

Stepwise synthesis of 2,6-difunctionalized ethyl pyrazolo[1,5-]pyrimidine-3-carboxylate site-selective cross-coupling reactions: experimental and computational studies.

A variety of novel disubstituted 2-(alknyl, aryl and arylamine)-6-alkynylpyrazolo[1,5-]pyrimidine derivatives was prepared sequential site-selective cross-coupling reactions from 2,6-dibromopyrazolo[1,5-]pyrimidine 3. The regio-controlled Sonogashira-type coupling of 3 with a wide range of terminal alkynes proceeded smoothly with excellent selectivity in favor of the C6-position through careful adjustment of the coupling conditions, followed by the subsequent introduction of alkynyl, aryl or arylamine groups at the C2-position the Sonogashira, Suzuki-Miyaura and Buchwald-Hartwig coupling reactions, respectively. These promising results allow for further use and diversification of the chemically and biologically interesting pyrazolo[1,5-]pyrimidine scaffold.

A framework for predicting academic orientation using supervised machine learning.

School guidance is declared an integral part of the education and training process, as it accompanies students in their educational and professional choices. Accordingly, the current situation in light of the Covid-19 epidemic requires a reconsideration of school guidance together with the methods of accompanying the student to choose the field that suits his/her personality, knowledge qualifications, perceptual and intellectual skills in order to achieve an excellent educational level that enables the learner to work in future professions. The current study aims to predict a student's potential and provide support for academic guidance.

Parental self-medication with antibiotics in a Tunisian pediatric center.

Introduction: Self-medication of antibiotics among children is a very common problem in Tunisia. Its prevalence isn't well established. The aims of this study are to evaluate parents' knowledge concerning antibiotic use, and identify the factors associated with this problem.

Cardiovascular risk factors in the Maghreb. A systematic review.

Objective: To assess the distribution of cardiovascular risk factors in Maghreb's countries.

Methods: It is a systematic review including articles and reports that applied the WHO "STEPwise" approach, or a similar approach, studying cardiovascular risk factors in the Maghreb countries: Tunisia, Morocco, Algeria, Libya and Mauritania between 2004 and 2018.

Results: We selected five articles, a report for each country.

IoT-school guidance: A holistic approach to vocational self-awareness & career path.

Schools are responsible for helping students in their vocational career development in the sense that they should sustain students in developing skills required by the job market. Pre-tertiary school guidance is an indispensable aspect, since poor scholar guidance is always associated with failure at school. In the context of career paths, we propose an innovative approach, a solution to guide pre-tertiary students to choose the optimum vocational path.

Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor.

A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying the substrates, the substituents, or the heating mode, it is possible to selectively synthesize indole, indolone (1,5,6,7-tetrahydroindol-4-one), or cinnoline (5,6,7,8-tetrahydrocinnoline) derivatives in moderate to excellent yields.

A Survey of IoT Security Based on a Layered Architecture of Sensing and Data Analysis.

The Internet of Things (IoT) is leading today's digital transformation. Relying on a combination of technologies, protocols, and devices such as wireless sensors and newly developed wearable and implanted sensors, IoT is changing every aspect of daily life, especially recent applications in digital healthcare. IoT incorporates various kinds of hardware, communication protocols, and services.

Erdheim-chester disease revealed by diabetes insipidus.

Erdheim-Chester disease (ECD) is a very rare and aggressive form of non-Langerhans histiocytosis with unclear pathogenesis. Because of the heterogeneity of clinical presentation, diagnosis is often challenging and delayed. Currently, Interferon alpha is the first line treatment that is associated with a better survival.

Potential role of liver enzyme levels as predictive markers of glucose metabolism disorders in a Tunisian population.

The relationship between liver enzymes and T2D risk is inconclusive. We aimed to evaluate the association between liver markers and risk of carbohydrate metabolism disorders, as well as their discriminatory power, for T2D prediction. This cross-sectional study enrolled 216 participants classified as normoglycemic, prediabetic, newly diagnosed diabetics, and diagnosed diabetics.

Performance evaluation of an IMDD optical OFDM-CDMA system.

In this paper, we propose a modulation technique for passive optical networks that harnesses two-dimensional prime hop system optical code division multiplexing access (OCDMA) and optical orthogonal frequency-division multiplexing (OFDM) for intensity modulation with direct-detection (IMDD) to enhance users' signal capacity in a cost-effective manner. The theoretical analysis is built from an analytical formula that takes into account both multiple-access interference and photodetector noise. Results show that OFDM-OCDMA with multiple users has similar performance to single-user conventional OOFDM for low transmitted powers.

From α-Bromomethylbutenolide to Fused Tri(Tetra) Cyclic Dihydrofurandiones through Barbier Reaction-Heck Arylation Sequence.

A Barbier reaction-Heck arylation sequence from α-bromomethylbutenolide to fused tri and tetracyclic lactones has been developed. The first step involving a Barbier reaction enabled installing -bromoaromatics in α-ylidene γ-lactones. The latter substrates were subjected to intramolecular Heck reaction conditions which selectively afforded 6,5,5 or 6,6,5 fused ring systems depending on the nature of the base employed.

A new locus on chromosome 22q13.31 linked to recessive genetic epilepsy with febrile seizures plus (GEFS+) in a Tunisian consanguineous family.

Background: Genetic epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome with extremely variable expressivity. The aim of our study was to identify the responsible locus for GEFS+ syndrome in a consanguineous Tunisian family showing three affected members, by carrying out a genome-wide single nucleotide polymorphisms (SNPs) genotyping followed by a whole-exome sequencing. We hypothesized an autosomal recessive (AR) mode of inheritance.

[Pathophysiology of complex regional pain syndrome (CRPS) type 1].

Background: If the pathophysiology of complex regional pain syndrome (CRPS) type 1 remains controversial, most authors agree on a combination in varying proportions, a sensitization of peripheral nerves.

Aim: To describe the state of advances in the physiopathology of complex regional pain syndrome type 1.

Methods: Bibliographic research and literature review performed by referring to databases (Medline, Science Direct)

Results: The physiopathology of complex regional pain syndrome type 1 remains still poorly understood and controversial.

Association of amyotrophic lateral sclerosis and Behcet's disease: is there a relationship? A multi-national case series.

Neurological involvement may be seen in 5-30% of the patients with Behcet's disease (BD). Occasionally, parenchymal neurological involvement in BD can present as a spinal cord syndrome. However, motor neuron disease-like presentation is extremely uncommon.

2,2'-Bis(methyl-ene)-3,3'-(2-thioxo-2,3-dihydro-1H-benzimidazole-1,3-di-yl)dipropane-nitrile.

In the title compound, C(15)H(12)N(4)S, the benzimidazole ring is essentially planar, with a mean deviation of 0.0082 (1) Å from the least-squares plane defined by the nine constituent atoms. In the crystal, inversion dimers linked by pairs of C-H⋯N hydrogen bonds occur.