Publications by authors named "Mpofu C"

The health system in Aotearoa New Zealand is predicated on equity in access to health services as a fundamental objective yet barriers to equitable access for migrant and refugees continue to exist. There is a paucity of studies that synthesise the experiences and realities of migrants, refugees and healthcare providers that hinder access to healthcare and provide recommendations to improve services. This review synthesised these barriers and recommendations, with an aim to improve equitable access to healthcare to migrants and refugees.

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There is renewed international effort to improve the health and well-being of migrants. For African migrants, theoretical frameworks designed to account for and guide interventions to address the underlying mechanisms that interact to influence health and well-being remain largely underdeveloped. The aim of this study was to address this gap by providing a unique socio-ecological framework with specific entry points for targeted health promotion action aimed at improving the health and well-being of African migrants living in Aotearoa New Zealand.

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Background: Medical cannabis is one of the most commonly reported treatments for chronic pain. The wide acceptance and research in alternative medicine have put medical cannabis in the limelight, where researchers are widely examining its therapeutic benefits, including treatment of chronic pain.

Objective: The purpose of this scoping review is to provide an overview of the perspectives on cannabidiol as an alternative treatment for chronic pain among health professionals and legal cannabis users.

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South Africa, with an estimated annual tuberculosis (TB) incidence of 360,000 cases in 2019, remains one of the countries with the largest burden of TB in the world. The identification of highly burdened TB areas could support public health policy planners to optimally target resources and TB control and prevention interventions. To investigate the spatial epidemiology and distribution of TB mortality in South Africa in 2010 and its association with area-level poverty and HIV burden.

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Primary CNS tumors are the leading cause of cancer-related death in pediatrics. It is essential to understand treatment trends to interpret national survival data. In Canada, children with CNS tumors are treated at one of 16 tertiary care centers.

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Foot-and-mouth disease (FMD) is a highly contagious disease that affects cattle, sheep, goats, pigs, and over 70 species of wildlife. FMD continues to be a major economic concern for livestock productivity in many countries. FMDV has seven serotypes O, A, Asia 1, C, and Southern Africa Territories (SAT) 1, 2, and 3.

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Background: Diffuse intrinsic pontine gliomas (DIPG) are midline gliomas that arise from the pons and the majority are lethal within a few months after diagnosis. Due to the lack of histological diagnosis the epidemiology of DIPG is not completely understood. The aim of this report is to provide population-based data to characterize the descriptive epidemiology of this condition in Canadian children.

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colonizes and is a pathogen of dogs and is being increasingly recognized from specimens from humans with various infections. We describe a case of bacteremia in a 4 month old pediatric oncology patient with clear evidence of transmission from the family pet.

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Mopani worms are abundant in Gwanda and sporadic in Tsholotsho though the two areas have similar climatic conditions. The study sought to determine nutritional factors that could be associated with distribution of Mopani worms in these two districts. Ten sampling points in undisturbed Mopani woodlands were established in each district.

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Article Synopsis
  • The study examines the emotional toll on parents with children facing life-limiting illnesses and highlights “hope” as a crucial coping mechanism.
  • It identifies four subprocesses of parental hope: Accepting Reality, Establishing Control, Restructuring Hope, and Purposive Positive Thinking.
  • The Delphi study involved 68 experts and revealed key themes supporting parental hope, leading to recommendations for improving caregiver support and suggesting further research directions.
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Migrants living in low incidence countries, including New Zealand (NZ), are disproportionately affected by tuberculosis (TB). This foreign-born group poses important challenges to achieving the national TB elimination targets. Thus, the aim of this study was to contribute to the understandingof factors that influence the incidence of TB among African migrants living in NZ.

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Article Synopsis
  • A study evaluated the effectiveness and safety of bevacizumab (BEV) for patients with recurrent glioblastoma who had already undergone first-line treatment with radiotherapy and temozolomide.
  • The TAMIGA trial involved randomizing patients after they experienced disease progression into two groups: one receiving lomustine (CCNU) with BEV and the other receiving CCNU with a placebo.
  • Results indicated that the trial was halted due to high dropout rates, with median survival slightly better in the CCNU + BEV group (6.4 months) compared to the CCNU + placebo group (5.5 months), but the difference was not statistically significant.
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Article Synopsis
  • - Medulloblastoma is the leading malignant brain tumor in children, with a general survival rate of about 70%, but outcomes after recurrence are not well-documented.
  • - An observational study in Canada from 1990 to 2009 tracked 550 children under 18 diagnosed with this cancer, revealing 1-year survival rates of 83.6%, falling to 72.5% at 5 years.
  • - Among the 31.2% of patients who experienced tumor recurrence, survival rates drastically decreased, with only 12.4% surviving at 5 years post-recurrence, highlighting the urgent need for new treatment strategies.
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Purpose: To conduct a metasynthesis of qualitative research exploring parents' psychosocial experiences during complex and traumatic life transitions related to caring for a child with a life-limiting (LLI) or life-threatening illness (LTI).

Background: Parents' experiences of caring for a child impacted by an LLI or LTI are not clearly understood, and holistic, comprehensive pediatric nursing care for parents who have children with LLI and LTIs continues to be developed as treatment improves and survival is extended.

Review Methods: Predetermined inclusion and exclusion criteria were used to review qualitative studies.

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This paper examines the issue of acid mine drainage in South Africa and environmental decision making processes that could be taken to mitigate the problem in the context of both conventional risk assessment and the precautionary principle. It is argued that conventional risk assessment protects the status quo and hence cannot be entirely relied upon as an effective tool to resolve environmental problems in the context of South Africa, a developing country with complex environmental health concerns. The complexity of the environmental issues is discussed from historical and political perspectives.

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Medical migration appears to be an increasing global phenomenon, with complex contributing factors. Although it is acknowledged that such movements are inevitable, given the current globalized economy, the movement of health professionals from their country of training raises questions about equity of access and quality of care. Concerns arise if migration occurs from low- and middle-income countries (LMICs) to high-income countries (HICs).

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The treatment of medulloblastoma, the most common malignant brain tumor in children, has evolved over the last few decades. The objectives of this paper were to determine the survival of pediatric medulloblastoma in Canada, to determine if there has been an improvement in the survival rates between the years of 1990 and 2009, inclusive, and to determine prognostic factors for survival. All patients under the age of 18 years diagnosed with medulloblastoma from 1990 to 2009, inclusive, in Canada were included.

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Medulloblastoma is the most common malignant brain tumor in children. There was a perception of pediatric neuro-oncologists that the incidence had declined in Canada. An epidemiological survey was undertaken to determine the incidence of this tumor in Canada and if a change had indeed occurred.

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The purpose of this secondary analysis was to develop an enhanced understanding of the experiences of parents who have children in treatment for cancer. Data collected from 16 parents (12 mothers and 4 fathers) were analyzed using Frank's dialogical narrative analysis. Findings demonstrated that parents' experiences were represented in chaos, restitution, and quest narratives.

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Objectives: To compare the effectiveness of rituximab versus an alternative tumour necrosis factor (TNF) inhibitor (TNFi) in patients with rheumatoid arthritis (RA) with an inadequate response to one previous TNFi.

Methods: SWITCH-RA was a prospective, global, observational, real-life study. Patients non-responsive or intolerant to a single TNFi were enrolled ≤4 weeks after starting rituximab or a second TNFi.

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Background: Hope has been found to support parents as they care for their child with a life-limiting or life-threatening illness. However, very little research focuses on the nursing care of parents of pediatric oncology patients, and therefore, nurses may have difficulty in understanding and supporting parental well-being.

Objective: The purpose of this qualitative study was to gain an understanding of the experience of hope for parents who care for their child in treatment for cancer.

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Background: Atypical teratoid rhabdoid tumours (ATRT) are aggressive brain tumours mostly occurring in early childhood. Largest published series arise from registries and institutional experiences (1-4). The aim of this report is to provide population-based data to further characterise this rare entity and to delineate prognostic factors.

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This study examined pain and distress from needles in children undergoing blood sampling as a function of adult-child interaction and type of venous access (i.e., central external venous lines, internalized ports, or peripheral access via venipuncture).

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Background: Carboplatin-based regimens have demonstrated activity in pediatric patients with low-grade glioma (LGG). However, carboplatin hypersensitivity reaction (Cb HSR) represents a common and limiting factor for the continuation of therapy.

Methods: The objectives of this study were to describe the prevalence, characteristics, and management of Cb HSR and to detail their impact on outcome.

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