Antioxidant and genotoxic properties of South African herbal extracts.

This study investigated the antioxidant and genotoxic properties of 13 South African herbal extracts. Results from the single-cell gel electrophoresis (Comet) assay indicated that there were profound differences between the plant extracts in their ability to produce DNA damage, which varied from highly genotoxic to protective. Similarly, water and methanol extracts of all the herbal preparations showed variable potencies in scavenging hydroxyl radicals, as measured by means of electron spin resonance spectrometery (ESR) with the spin trap alpha-phenyl-N-tert-butylnitrone (PBN).