Publications by authors named "Mozhgan Aghajani"
Article Synopsis
- This study investigates the effects of acute sleep deprivation (ASD) before a heart attack (myocardial ischemia) on oxytocin release from brain neurons and its relationship with sympathetic nervous system activity, which may influence heart remodeling after a heart attack.
- The research involved inducing sleep deprivation and heart attacks in animals, followed by blood sampling and evaluation of heart and brain tissues for biochemical analysis at two different time points.
- Results showed that sleep deprivation before the heart attack increased oxytocin levels and provided protective effects to the heart, such as reduced damage and fibrosis, suggesting that sleep deprivation activates a protective response that benefits heart health.
Disturbed sleep or sleep loss due to vocational or lifestyle changes following MI is a common problem that may affect many physiological processes involved in left ventricle (LV) remodeling. Herein, we proposed that experience of sleep disruption and/or restriction after myocardial infarction (MI) may aggravate cardiac extracellular matrix remodeling and induce apoptosis in the cardiomyocytes. MI was induced in adult male rats by permanent ligation of the left anterior descending coronary artery.
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