Publications by authors named "Mozam Ali"

We describe the MalariaGEN Pf7 data resource, the seventh release of genome variation data from the MalariaGEN network.  It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented.  For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations.

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Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.

Methods: Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode.

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Article Synopsis
  • MalariaGEN is a global data-sharing network focused on studying the genomic epidemiology of malaria, releasing new genome variation data from 7,000 samples across 28 malaria-endemic countries.
  • The project generated high-quality genotype data on 3 million single nucleotide polymorphisms (SNPs) and identified drug resistance factors, revealing that nearly all samples showed some genetic resistance to antimalarial drugs.
  • The ongoing expansion of this open data resource aims to enhance research on malaria's evolution and improve tools necessary for malaria surveillance and elimination efforts.
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1. Dilatation of the cerebral vasculature is recognised to be involved in the pathophysiology of migraine. Furthermore, elevated levels of prostaglandin E(2) (PGE(2)) occur in the blood, plasma and saliva of migraineurs during an attack, suggestive of a contributory role.

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