Can clonidine as a pre-anaesthetic drug decrease bleeding during rhinoplasty surgery?

Clonidine is an antihypertensive drug which acts through facilitation of Alph-2 post-synaptic receptors and in addition to its antihypertensive, anti-anxiety and analgesic effects, its beneficial effects in reducing the bleeding during Neurosurgery and Orthopedics surgeries, delicate surgeries of ear and nasal and sinus endoscopy have been proved. In this study we discuss the effects of this drug in reducing bleeding during rhinoplasty surgery. A double-blinded clinical trial 80 patients have been conducted 40 patients received 5 µg/Kg of oral Clonidine, and 40 patients where placebo.