ShinyCore: An R/Shiny program for establishing core collection based on single nucleotide polymorphism data.

Background: Managing and investigating all available genetic resources are challenging. As an alternative, breeders and researchers use core collection-a representative subset of the entire collection. A good core is characterized by high genetic diversity and low repetitiveness.

Predictors of treatment failure following coil embolization of intracranial aneurysms.

We present a retrospective review of 357 consecutive patients with 419 aneurysms treated with coil embolization. Although incomplete occlusion and recurrence of intracranial aneurysms following coil embolization is a well-known problem, the factors that influence and predict treatment failure are still debated. For this study, we excluded non-coiling endovascular techniques (flow diversion) and non-saccular aneurysms (fusiform).

An update to the Raymond-Roy Occlusion Classification of intracranial aneurysms treated with coil embolization.

Background: The Raymond-Roy Occlusion Classification (RROC) is the standard for evaluating coiled aneurysms (Class I: complete obliteration; Class II: residual neck; Class III: residual aneurysm), but not all Class III aneurysms behave the same over time.

Methods: This is a retrospective review of 370 patients with 390 intracranial aneurysms treated with coil embolization. A Modified Raymond-Roy Classification (MRRC), in which Class IIIa designates contrast within the coil interstices and Class IIIb contrast along the aneurysm wall, was applied retrospectively.

Angiographic outcome of intracranial aneurysms with neck remnant following coil embolization.

Background: The degree of aneurysm occlusion following coil embolization has an impact on aneurysm recanalization.

Objective: To explain the natural history of intracranial aneurysms with neck remnant, Raymond-Roy Occlusion Classification (RROC) class II.

Methods: A single-center, retrospective study of 198 patients with 209 aneurysms treated with coil embolization that were initially either RROC class I or II.

Analysis of early angiographic outcome using unique large diameter coils in comparison with standard coils in the embolization of cerebral aneurysms: a retrospective review.

Background: The initial experience with the large diameter Penumbra Coil 400 (PC400) system has been positive regarding safety, efficacy, improved packing density and cost effectiveness, but follow-up data are limited.

Methods: This is a single-center retrospective review of 76 aneurysms treated with PC400 coils compared with 301 aneurysms treated with a variety of different bare platinum and bioactively coated coils. Atypical and giant aneurysms were excluded as well as those that had undergone previous treatment.

Initial experience with Penumbra Coil 400 versus standard coils in embolization of cerebral aneurysms: a retrospective review.

Background And Purpose: The Penumbra Coil 400 System (PC 400) is the newly introduced platinum coil system designed specifically to enhance filling efficiency by increasing coil diameter. Our goal was to study the packing and treatment advantage of the PC 400's unique geometric configuration compared with conventional coils (controls).

Materials And Methods: 16 aneurysms embolized with the PC 400 in 2011 were compared with 79 equally matched aneurysms embolized with conventional coils from 2004 to 2011.

Intracranial aneurysms: endovascular treatment.

The incidence of subarachnoid hemorrhage is estimated at 5 to 10 per 100,000 per year. In patients who survive the initial hemorrhage, the repeat hemorrhage rate is 15% to 20% in the first 2 weeks after presentation and is associated with devastating clinical outcomes even graver than the initial rupture. The current options for aneurysm treatment are surgical clipping and, since the mid-1990s, neuroendovascular coil embolization.

Gossypiboma of the abdomen.

Intra-abdominal cysts may rise from a variety of organs. However, foreign-body reaction and cyst formation should be considered in the differential diagnosis. In this report, we describe the finding of a preoperatively undetected gossypiboma.

Target of the transcriptional activation function of phage lambda cI protein.

Activation of transcription initiation by the cI protein of phage lambda is thought to be mediated by a direct interaction between cl and RNA polymerase at the PRM promoter. Two negatively charged amino acid residues in the DNA binding domain of cI play a key role in activation, suggesting that these residues contact RNA polymerase. The subunit of RNA polymerase involved was identified by selecting polymerase mutants that restored the activation function of a mutant form of cI protein.

Hierarchies of base pair preferences in the P22 ant promoter.

Oligonucleotide-directed mutagenesis was used to complete a collection of mutations in the -35 and -10 hexamers of the ant promoter of Salmonella phage P22. The effects of all 36 single-base-pair substitutions on promoter strength in vivo were measured in strains carrying the mutant promoters fused to an ant-lacZ gene on a single-copy prophage. The results of these assays show that certain consensus base pairs are more important than others; in general, the least-critical positions are among the most poorly conserved.

A mutant Escherichia coli sigma 70 subunit of RNA polymerase with altered promoter specificity.

A mutation is described that alters the promoter specificity of sigma 70, the primary sigma factor of Escherichia coli RNA polymerase. In strains carrying both the mutant and wild-type sigma gene (rpoD), the mutant sigma causes a large increase in the activity of mutant P22 ant promoters with A.T or C.