Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender Persons.

Context: Liver fat content and visceral fat volume are associated with insulin resistance and cardiovascular disease and are higher in men than in women.

Objective: To determine the effect of estradiol and testosterone treatment on liver fat and visceral fat in transgender persons.

Design: Open-label intervention study (SHAMVA) with a 1-year follow-up.

The efficacy of aspirin to inhibit platelet aggregation in patients hospitalised with a severe infection: a multicentre, open-label, randomised controlled trial.

Patients with severe infection have an increased risk of cardiovascular events. A possible underlying mechanism is inflammation-induced platelet aggregation. We investigated whether hyperaggregation occurs during infection, and whether aspirin inhibits this.

The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasis.

Background: Cardiovascular risk is increased in transgender persons using gender-affirming hormone therapy. To gain insight into the mechanism by which sex hormones affect cardiovascular risk in transgender persons, we investigated the effect of hormone therapy on markers of inflammation and hemostasis.

Methods: In this exploratory study, 48 trans women using estradiol patches plus cyproterone acetate (CPA) and 47 trans men using testosterone gel were included.