[Human cases of hydrophobia in the Russian Federation].

The analysis of 29 human cases of hydrophobia registered in the Russian Federation in 2000-2001 is presented. Dogs appeared to be the main infection source (50% of cases). An increased proportion of cats (17.

[The efficacy of a cultured rabies vaccine studied in guinea pigs preliminarily infected with a fixed rabies virus].

In experiments of curative vaccination, carried out with the use of an experimental model similar to the current practice of treatment with antirabies preparations, the advantages of using tissue-culture rabies vaccine with immunogenic potency equal to 1.3 international units (I. U.

[The localization and distribution of the antigen of the fixed rabies virus in the central nervous system of animals studied by the fluorescent antibody method].

The immunofluorescent study of cryostatic sections of the main structures of the brain of animals infected with fixed rabies virus, strain CVS, was carried out by the direct modification of the fluorescent antibody method. Definite regularities in the distribution of rabies virus antigen after the intracerebral distribution of rabies virus were established. The antigen could be detected mainly in neurons of the cortex, the hippocampus major, subcortical formations and was absent in the truncal formations of the brain and the cerebellum.

[The efficacy of a cultured rabies vaccine studied on guinea pigs previously infected with the rabies street virus].

In this work materials on the development of an experimental model for the study of rabies vaccines are presented. The comparative study of different immunization schedules for vaccines with different protective potency has been carried out. Guinea pigs infected with street rabies virus, strain k, were used as an experimental model.

[Effect of specific antibodies on active immunity development in those inoculated with an antirabies vaccine].

The study of the effect of gamma globulin introduced in different doses (0.5 and 0.25 ml/mg) in combination with Fermi rabies vaccine (observations on humans were made) and with cerebral rabies vaccine inactivated by UV irradiation (in animal experiments) demonstrated that the injection of the higher doses of gamma globulin resulted in lower geometrical mean of antibody titers.

[Participation of vaccinia virus in the pathogenesis of different clinical forms of postvaccinal complications. I. Frequency of vaccinia virus detection in the vaccinted who have usual and complicated reactions to vaccination].

The virological examination of 1365 samples taken from 469 children vaccinated against smallpox revealed considerable differences in the frequency and the time of vaccinia virus detection in different clinical forms of postvaccinal pathology as compared with uncomplicated vaccinal process. During the postvaccinal period taking its normal course vaccinia virus was isolated from 7.3% of children only from the pharynx till day 8 following vaccination.

[Experimental study of the ability of different strains of vaccinia virus to induce autoantibody formation].

The intensity of autoantibody production to red blood cell lysate in guinea pigs inoculated with smallpox vaccine prepared from different strains was studied at 7, 14, 21 and 28 days after vaccine inoculation. The dynamics of autoantibody production in the same animals as well as the influence of altered responsiveness of the animals pre-treated with dyphtheria toxin on the intensity of autoantibody production were determined. The autoantibody-inducing activity correlated with reactogenicity of the strains and was most marked in the white cloned variant of the Tashkent strain, slightly lower in the L-IVP strain being intermediate in this criterion and insignificant in poorly reactogenic EM-63 and B-51 strains.