Propranolol-mediated attenuation of MMP-9 excretion in infants with hemangiomas.

Importance: Infantile hemangiomas (IHs) vary substantially in localization and extent of tissue involvement, but IH biological progression is remarkably unique and predictable. Propranolol is an effective treatment for symptomatic IH, but its mechanism of action remains unknown and understudied.

Objective: To compare excreted proteins in infants with IH being treated with propranolol vs prednisolone.

Lithium as a potential adjuvant to 131I therapy of metastatic, well differentiated thyroid carcinoma.

As lithium inhibits the release of iodine from the thyroid but does not change iodine uptake, it may potentiate 131I therapy of thyroid cancer. The effects of lithium on the accumulation and retention of 131I in metastatic lesions and thyroid remnants were evaluated in 15 patients with differentiated thyroid carcinoma. Two 131I turnover studies were performed while the patients were hypothyroid.

Phloretin inhibits cellular uptake and nuclear receptor binding of triiodothyronine in human hep G2 hepatocarcinoma cells.

Phloretin is an inhibitor of the mammalian glucose transporter and the iodothyronine-5'-deiodinase. We examined the effects of phloretin on cellular and nuclear uptake of [125I]T3 in cultured human Hep G2 hepatocarcinoma cells. The initial rate of T3 uptake was energy dependent and saturable with both a high affinity (Km = 3.