Curtailing Quorum Sensing in Pseudomonas aeruginosa by Sitagliptin.

Pseudomonas aeruginosa coordinates the secretion of virulence factors through quorum sensing. Quorum sensing inhibitors can attenuate the pathogenesis of bacteria and help the immune system to eradicate them without targeting the bacterial growth. This study aimed to explore the anti-quorum sensing and anti-virulence activities of sitagliptin against P.

Glyceryl trinitrate blocks staphyloxanthin and biofilm formation in .

Background: is an important nosocomial bacterium that is responsible for a number of infections that may be fatal. The treatment of such infections is limited by emergence of antibiotic resistance. Targeting virulence of may provide an alternative option to antibiotic that may bypass the emergence of resistant strains due to lack of stress on viability.

Repurposing metformin as a quorum sensing inhibitor in .

Background: Quorum sensing is a mechanism of intercellular communication that controls the production of virulence factors in . Inhibition of quorum sensing can disarm the virulence factors without exerting stress on bacterial growth that leads to emergence of antibiotic resistance.

Objectives: Finding a new quorum sensing inhibitor and determining its inhibitory activities against virulence factors of PAO1 strain.

Glyceryl trinitrate is a novel inhibitor of quorum sensing in .

Background: Targeting quorum sensing is an alternative approach to antibiotics.Targeting quorum sensing-regulated virulence will disarm the pathogen without exerting pressure on its growth. As a result, emergence of resistance is avoided and the immune system can easily eradicate bacteria.