Publications by authors named "Mousumi Sen"
We describe a safe and standardized perfusion protocol for studying brain pathology in high-risk autopsies using a custom-designed low-cost infection containment chamber and high-resolution histology. The output quality was studied using the histological data from the whole cerebellum and brain stem processed using a high-resolution cryohistology pipeline at 0.5 μm per pixel, in-plane resolution with serial sections at 20-μm thickness.
View Article and Find Full Text PDFBackground And Aim: Though rodenticidal hepatotoxicity is reported from India, there is no systematic study to assess its magnitude. This study aimed to assess exposure to rodenticide as a risk factor for acute hepatotoxicity in Tamil Nadu, India.
Methods: We retrospectively analyzed acute hepatotoxicity caused by ingestion of hepatotoxin or potentially hepatotoxic drug overdose across 15 hospitals in 6 districts of Tamil Nadu from 1 January 2019 to 30 June 2019.
Article Synopsis
- - The study investigates how high levels of von Willebrand factor (VWF) affect survival in patients with liver damage caused by rodenticides, with a focus on whether lowering VWF through treatments like N-acetyl cysteine (NAC) and plasma exchange (PLEX) can improve outcomes.
- - Data from 24 patients were analyzed, showing that as VWF levels increased, the likelihood of poor outcomes (such as death or being discharged in a terminal condition) also increased, indicating a strong correlation between VWF levels and survival rates in acute liver failure (ALF) cases.
- - The findings suggest that monitoring and potentially reducing VWF could be beneficial in treating rodenticide-induced liver damage, highlighting its role as
Dowry deaths in the newly married brides are a burning problem of southern India. The objective of the current study was to identify the risk groups. This prospective study was carried out on 140 cases.
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