Neutrophil-to-lymphocyte ratio: link to congestion, inflammation, and mortality in outpatients with heart failure.

Background: The neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation, but its associations with clinical characteristics, signs of congestion and outcome in patients with chronic heart failure (HF) are unknown.

Methods And Results: We enrolled 4702 ambulatory patients with HF and either left ventricular systolic dysfunction or high N-terminal pro-B-type natriuretic peptide (NTproBNP) (≥125 ng/L). Compared with those in the lowest quartile of NLR (≤2.

Validation of novel predictors for early detection of cancer therapeutics-related cardiac dysfunction.

Background: Early identification of cardiotoxicity of chemotherapy is crucial. Gene expression is considered a promising tool.

Aim: To validate the new speckle tracking values, high-sensitive (Hs) troponin and expression of TNNI3K and RyR2 genes for early detection of cardiotoxicity.

Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis.

Background: Immune responses play a significant role in hypertension, though the importance of key inflammatory mediators remains to be defined. We used a systematic literature review and meta-analysis to study the associations between key cytokines and incident hypertension.

Methods: We performed a systematic search of Pubmed/Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), for peer-reviewed studies published up to August 2022.