Parenteral nutrition-associated cholestasis in neonates: multivariate analysis of the potential protective effect of taurine.

Background: Neonates receiving parenteral nutrition (PN) are at risk for PN-associated cholestasis (PNAC); however, no preventive factors for PNAC have been clearly identified. Despite reports suggesting that taurine may prevent PNAC in neonates, such an effect of taurine has not yet been definitively demonstrated. We determined whether taurine supplementation reduces the incidence of PNAC in premature or critically ill neonates.

Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasis.

Objective: To determine whether cholecystokinin-octapeptide (CCK-OP) would prevent or ameliorate parenteral nutrition-associated cholestasis (PNAC) among high-risk neonates treated with total parenteral nutrition.

Study Design: This was a multicenter, double-blind, randomized, controlled trial conducted between 1996 and 2001.

Patients: Neonates at risk for the development of PNAC included very low birth weight neonates and those with major surgical conditions involving the gastrointestinal tract.