Sex Differences in the Association Between Vascular Risk Factors and Cognitive Decline: A UK Biobank Study.

Background: Age-related cognitive decline is accelerated by vascular risk factors for cerebral small vessel disease. However, the association of vascular risk factors with cerebral small vessel disease contributing to the sex differences in cognitive decline remains unclear.

Objectives: The purpose of this study was to evaluate sex differences in cognitive decline and the association between vascular risk factors and cognitive decline by sex.

Rhodium-Catalyzed Addition of Organozinc Iodides to Carbon-11 Isocyanates.

Amides were prepared using rhodium-catalyzed coupling of organozinc iodides and carbon-11 (C, = 20.4 min) isocyanates. Nonradioactive isocyanates and sp or sp organozinc iodides generated amides in yields of 13%-87%.