Publications by authors named "Moussa Seck"

Article Synopsis
  • Sickle cell emergencies are a leading reason for hospitalizations in patients with sickle cell disease, causing significant financial strain and increased health risks.
  • A study tracked 112 adults with sickle cell emergencies over four months, revealing a 38.41% readmission rate within 30 days, predominantly due to vaso-occlusive crises and acute chest syndrome.
  • Key factors predicting readmission included having a job, low levels of fetal hemoglobin, and certain blood cell counts (neutrophilia, lymphocytosis, thrombocytosis).
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Article Synopsis
  • The study focused on managing acute pain in adults with sickle cell disease (SCD), particularly during vaso-occlusive crises (VOC), which occur when sickle cells block microvessels, leading to severe pain.* -
  • An analysis of 118 cases revealed that most patients (86.61%) had the SS sickle cell phenotype, with predominant pain in the lower limbs and spine, and a majority experiencing intense to unbearable pain.* -
  • The findings underscore the effectiveness of multimodal analgesia as a treatment approach, while also indicating significant variability in pain management practices, suggesting a need for tailored recommendations.*
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The Hodgkin variant Richter syndrome (HvRS) is an infrequent complication occurring in 1% of lymphocytic lymphoma/chronic lymphocytic leukemia patients. We report a case of HvRS diagnosed in Sub-Saharan Africa. A 63-year-old patient was consulted for the investigation of an abdominal mass that had been evolving for 5 years prior to admission.

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SUMMARYCOVID-19 infection has emerged as a comorbidity that can significantly increase morbidity and mortality in sickle cell patients with ACS (acute thoracic/chest syndrome). The aim of our study was to assess COVID-19-related morbidity and mortality in sickle cell patients with ACS. This was a retrospective, descriptive study of patient records followed over a 36-month period from January 2020 to December 2022.

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The degree of anaemia in sickle cell disease (SCD) is a well-known contributor to morbidity and mortality. We aimed to explore the factors affecting haemoglobin (Hb) level in African SCD patients, considering haemolysis biomarkers (LDH and bilirubin level, and reticulocyte count), leucocyte and platelet counts and socio-demographic characteristics (gender, age group, country of residence and BMI). The research was part of the CADRE multinational cohort and involved 3699 SCD patients living in Mali, Senegal, Ivory Coast, Democratic Republic of Congo, Gabon and Cameroon: 2936 SS/Sβ0, 587 SC and 176 Sβ + patients with median Hb level of 8, 11.

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Rosai-Dorfman disease (RDD) is a benign histiocytic proliferation that results in nodal and extranodal involvements. It is a rare disease, with fewer than 1,000 cases reported in the literature, which explains its lack of knowledge by physicians and the lack of codified therapeutic strategies. We report the case of an 8-year-old girl who presented a rapidly progressive cervical lymph node mass; the diagnosis of RDD was made based on histology and immunohistochemistry.

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Objectives: The aim of this study was to describe the morbidity and mortality of homozygous sickle cell disease after the age of 40.

Methods: This was a cohort study of 209 patients followed from 1994 to 2022. All hemoglobin electrophoresis-confirmed SS sickle cell patients over 40 years were included.

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Blood transfusion support predisposes transfused children to the risk of erythrocyte alloimmunization in Sub-Saharan Africa. A cohort of 100 children receiving one to five blood transfusions were recruited for screening and identification of irregular antibodies using gel filtration technique. The mean age was 8 years and the sex-ratio at 1.

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Purpose: Erectile dysfunction is a dreadful complication of priapism especially with delay in diagnosis and management. The lack of awareness of priapism as a vaso-occlusive complication of sickle cell disease (SCD) is more concerning. The objective of this study was to evaluate the burden of priapism in adult Senegalese males adults with sickle cell disease.

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Objective: The aim of this review is to clarify the prevalence, pathophysiology and clinical presentation of enuresis and overactive bladder in sickle cell patients.

Materials And Methods: This narrative review of the literature was conducted in March 2022 by running a search in PubMed, Embase, Scopus and Cochrane databases without publication date limitation, using the following keywords: enuresis or nocturia or overactive bladder or urinary incontinence or bedwetting and sickle cell.

Results: Eight cross-sectional studies were included, six of which had a non-sickle cell control population.

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Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state.

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Homozygous sickle cell disease (HSCD) is characterized by multiorgan morbidity and an increased risk of early death. We aim to describe the mortality rate, causes, and risk factors of death in HSCD between 2011 and 2020. We conducted a retrospective study with a duration of 10 years in the cohort of 2348 HSCD patients.

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Objective: Sickle cell anemia (SCA) can cause substantial kidney dysfunction resulting in sickle cell nephropathy, which may be affected by the presence of modifier genes. This study evaluates the effects of some modifier genes on sickle cell nephropathy.

Methods: Patients living with SCA were recruited.

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Article Synopsis
  • In Africa, where hemophilia treatment access is limited, a study evaluated the effectiveness of low-dose prophylaxis (LDP) in reducing bleeding episodes among patients in sub-Saharan Africa.
  • The study involved 15 children with hemophilia receiving low-dose clotting factors, resulting in significant decreases in annualized bleeding rates, joint bleeding, and improvements in joint health and functional independence over three years.
  • The findings suggest that LDP improves clinical outcomes without increasing inhibitor risk, highlighting the importance of extended half-life clotting factor concentrates for better patient adherence in resource-limited settings.
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Objective: The aim of this study was to assess incidence, risk factors, treatment and outcome of LTB in Senegalese people with hemophilia (PWH).

Methods: We analyzed the characteristics of LTB in a cohort of 274 PWH after 10 years of follow-up.

Results: We included 274 patients (241 HA and 33 HB).

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Objective: We evaluated the relevance of using the smudge cell percentage in the blood smear as a prognostic marker in CLL.

Methods: In this prospective study, 42 untreated Senegalese patients with CLL were enrolled. The diagnosis was established, based on the peripheral blood count and flow cytometry using the Matutes score.

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Several studies conducted in America or Europe have described major cardiac remodeling and diastolic dysfunction in patients with sickle cell disease (SCD). We aimed at assessing cardiac involvement in SCD in sub-Saharan Africa where SCD is the most prevalent. In Cameroon, Mali and Senegal, SCD patients and healthy controls of the CADRE study underwent transthoracic echocardiography if aged ≥10 years.

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Background: Sickle cell trait (SCT) is a benign condition of sickle cell disease. Nevertheless, previous reports showed that SCT carriers have increased blood viscosity and decreased vascular reactivity compared to non-SCT carrier. The benefit of regular exercise on vascular function has been well documented in the general population but no study focused on the SCT population.

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Article Synopsis
  • The study examines the relationship between steady-state hemolysis and vascular complications in sickle cell disease (SCD) patients from West and Central Africa, highlighting the need for context-specific research beyond North American data.
  • Researchers analyzed 2,407 SCD patients using a composite index for hemolytic intensity to assess complications like tricuspid regurgitant jet velocity (TRV), microalbuminuria, and leg ulcers.
  • Findings suggest that severe anemia is linked to certain vascular issues, but increased hemolysis does not independently explain these complications, indicating that other factors, such as nutrition and infections, may contribute to SCD-related vasculopathy.
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Objectives: The aim of this study was to evaluate the maternal and fetal complications in pregnant patients with sickle cell disease (SCD) and find risk factors of stillbirth.

Method: We conducted a prospective study in pregnant women with SCD. Demographic characteristics, maternal and fetal morbi-mortality, and outcome of pregnancies were described.

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