Publications by authors named "Moussa Lingani"
Article Synopsis
- The study evaluated the effectiveness and tolerability of the antimalarial drug ganaplacide in combination with lumefantrine solid dispersion (LUM-SDF) for treating uncomplicated falciparum malaria across various age groups in a Phase II clinical trial.
- The trial consisted of three parts: a run-in phase assessing pharmacokinetic interactions, a regimen comparison in adults and adolescents, and a dosage assessment in children aged 2 to under 12 years.
- Results indicated that co-administration of ganaplacide and LUM-SDF did not significantly alter drug exposure levels, with both drugs showing adequate exposure for efficacy across different age and weight groups, despite some variability.
Article Synopsis
- Influenza viruses account for only 20% of severe acute respiratory infections (SARI) in Burkina Faso, with other viral causes largely uninvestigated.
- A study tested 1,541 specimens from SARI patients between 2016 and 2019, finding that 76.1% of those negative for influenza contained other respiratory viruses, primarily human rhinoviruses.
- Infants aged 1-4 years were the most affected demographic, indicating a need for enhanced surveillance that includes common non-influenza pathogens to improve clinical and preventive measures.
Article Synopsis
- * The study, conducted from August 2019 to March 2020, involved 594 pregnant women, revealing a 54.4% anemia prevalence, with moderate and severe cases at 49.2% and 5.2%, respectively.
- * Key factors contributing to anemia included being under 20 years old and having malaria; the research suggests that enhancing malaria prevention efforts is crucial for young pregnant women to combat maternal anemia.
A new tool for assessing hepatitis B treatment eligibility in Africa.
Lancet Gastroenterol Hepatol
April 2024
Background: Emergence of drug resistance demands novel antimalarial drugs with new mechanisms of action. We aimed to identify effective and well tolerated doses of ganaplacide plus lumefantrine solid dispersion formulation (SDF) in patients with uncomplicated Plasmodium falciparum malaria.
Methods: This open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial was conducted at 13 research clinics and general hospitals in ten African and Asian countries.
In highly endemic countries for hepatitis B virus (HBV) infection, childhood infection, including mother-to-child transmission (MTCT), represents the primary transmission route. High maternal DNA level (viral load ≥ 200,000 IU/mL) is a significant factor for MTCT. We investigated the prevalence of HBsAg, HBeAg, and high HBV DNA among pregnant women in three hospitals in Burkina Faso and assessed the performance of HBeAg to predict high viral load.
View Article and Find Full Text PDFBackground: Exposure during pregnancy to malaria and sexually-transmitted infections is associated with adverse birth outcomes including low birth weight (LBW). This study aimed at assessing if the adjunction of two doses of azithromycin to sulfadoxine-pyrimethamine for the intermittent preventive treatment of malaria in pregnancy can reduce LBW.
Methods: A two parallel-groups, open-label randomized controlled trial involving pregnant women (16 to 35 years of age and 12 to 24 weeks of gestation as confirmed by last menstrual period or fundal height) was conducted in rural Burkina Faso.
Background And Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) particularly the variants of concern coinfections with influenza is a public health concern in Africa. We aimed to characterize the SARS-CoV-2 variants and determine the rate of coinfections with influenza in Burkina Faso.
Methods: COVID-19 surveillance study was conducted between August 2021 and January 2022 using reverse transcription polymerase chain reaction (RT-PCR).
Background: The contribution of artefenomel to the clinical and parasiticidal activity of ferroquine and artefenomel in combination in uncomplicated Plasmodium falciparum malaria was investigated.
Methods: This Phase 2a, randomized, open-label, parallel-group study was conducted from 11th September 2018 to 6th November 2019 across seven centres in Benin, Burkina Faso, Gabon, Kenya, and Uganda. Patients aged ≥ 14-69 years with microscopically confirmed infection (≥ 3000 to ≤ 50,000 parasites/µL blood) were randomized 1:1:1:1 to 400 mg ferroquine, or 400 mg ferroquine plus artefenomel 300, 600, or 1000 mg, administered as a single oral dose.
Article Synopsis
- The WHO emphasizes the need for continuous malaria surveillance in endemic regions to focus targeted interventions on at-risk populations.
- A study in rural Burkina Faso involving 1,067 first antenatal care attendees found a 16.1% prevalence of malaria, with significant associations linked to factors like age under 20, anemia, lack of bed net use, and absence of preventive treatment.
- The findings indicate a critical need to enhance malaria prevention strategies during early antenatal care visits to reduce negative health effects for pregnant women and their babies.
Article Synopsis
- Low birth weight (LBW) is a significant cause of neonatal mortality in developing countries, with rising concern in sub-Saharan Africa due to limited data for effective intervention.
- A study in Yako, Burkina Faso, involved a survey of 600 mothers and their newborns, finding an 11% prevalence of LBW and identifying key risk factors such as maternal malaria, low preventive treatment uptake, and being a primigravid mother.
- Results indicate that despite mothers’ antenatal visits, these factors contribute to LBW, highlighting the need for improved maternal health strategies in rural areas.
Article Synopsis
- The study investigates the prevalence of malaria and sexually transmitted/reproductive tract infections (STI/RTI) among pregnant women in rural Burkina Faso, aiming to identify efficient interventions for better pregnancy outcomes.
- It includes a survey of 402 pregnant women attending clinics, testing for malaria and various STIs, revealing a 12.9% rate of malaria alongside at least one STI/RTI coinfection, with bacterial vaginosis being the most common coinfection.
- The findings indicate that only 10% of these coinfections showed symptoms, suggesting a significant number of cases would go undetected with symptom-based screening methods, highlighting the need for more effective diagnostic approaches in antenatal care.
Background: Detailed characteristics of Hepatitis C virus (HCV) infection in Burkina Faso are scarce. The main aim of this study was to assess HCV seroprevalence in various settings and populations at risk in Burkina Faso between 1990 and 2020. Secondary objectives included the prevalence of HCV Ribonucleic acid (RNA) and the distribution of HCV genotypes.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on estimating the prevalence of low birthweight (LBW) in the rural area of Nanoro, Burkina Faso, where limited data previously existed.* -
- Of the 291 newborns examined, 12% were found to have LBW, with significant associations linked to factors like being a first-time mother, having a history of stillbirth, and not using insecticide-treated bed nets during pregnancy.* -
- The findings highlight a pressing public health issue in Burkina Faso and suggest a need to improve antenatal care services to better address risks associated with low birthweight.*
Background: Malaria and curable sexually transmitted infections (STIs) are severe infections associated with poor pregnancy outcomes in sub-Saharan countries. These infections are responsible for low birth weight, preterm birth, and miscarriage. In Burkina Faso, many interventions recommended by the World Health Organization were implemented to control the impact of these infections.
View Article and Find Full Text PDFBackground: Malaria and curable sexually transmitted infections (STI) are the most common curable infections known to have a severe impact on pregnancy outcomes in sub-Saharan Africa. This study aims to assess the marginal and joint prevalence of symptomatic cases of malaria and STI in pregnant women living in rural settings of Burkina Faso and their associated factors, after more than a decade of the introduction of intermittent preventive treatment (IPT-SP).
Methods: We carried out an observational study in two health districts in rural Burkina, namely Nanoro and Yako.
Background: This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after hepatitis B vaccine was introduced in the national immunization scheduled for children.
Methods: In 2018, a community-based, random sampling strategy with probability proportional to population size was conducted in Nanoro to investigate the prevalence of viral hepatitis in children and their mothers. Sociodemographic, vaccination history and risk factors were assessed by interview and health books.
Background: Artemisinin-based combination therapy (ACT) is recommended to improve malaria treatment efficacy and limit drug-resistant parasites selection in malaria endemic areas. 5 years after they were adopted, the efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ), the first-line treatments for uncomplicated malaria were assessed in Burkina Faso.
Methods: In total, 440 children with uncomplicated Plasmodium falciparum malaria were randomized to receive either AL or ASAQ for 3 days and were followed up weekly for 42 days.
Background: The global health transition is linked with an increased burden of non-communicable diseases with cardiovascular diseases leading the epidemic. In sub-Saharan Africa (SSA), the prevalence of obesity has increased during the past decades and there is a need to investigate the associated driving factors. In Burkina Faso obesity remains low, especially in rural areas.
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- Hepatitis B virus (HBV) infection is a significant public health issue in Burkina Faso, contributing to liver cancer and cirrhosis, prompting the adoption of a national strategic plan for hepatitis elimination in 2017.
- This study conducted a systematic review and meta-analysis of 22 papers published from 1996 to 2017, involving nearly 100,000 participants, to estimate the prevalence of HBV in the country.
- The overall HBV prevalence was found to be 11.21%, with higher rates in specific populations and rural areas, and a trend of decreasing prevalence following the introduction of universal vaccination.
We report 1,327 probable cases of dengue in Burkina Faso in 2016. Of 35 serum samples tested by a trioplex test, 19 were confirmed dengue virus (DENV)‒positive: 11 DENV-2, 6 DENV-3, 2 nontypeable, and 1 DENV-2/DENV-3 co-infection. Molecular testing should be conducted to correctly identify causative agents in this complex infectious disease landscape.
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- Artemether-lumefantrine (AL) was studied for treating uncomplicated malaria in infants under 5 kg, as existing research primarily focuses on children over 5 kg.
- A multicenter study found that AL dispersible was effective, reporting a 100% cure rate at days 28 and 42 among the participants, with mild to moderate side effects.
- Although AL demonstrated efficacy and tolerability, the study revealed higher levels of artemether and dihydroartemisinin in infants, raising concerns about potential neurotoxicity and making it impossible to provide dosage recommendations for this weight group.
Background: The recent reports on the decreasing susceptibility of Plasmodium falciparum to artemisinin derivatives along the Thailand and Myanmar border are worrying. Indeed it may spread to India and then Africa, repeating the same pattern observed for chloroquine resistance. Therefore, it is essential to start monitoring P.
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