Publications by authors named "Moussa Fafa Cisse"
Background: Neonatal infection constitutes one of Senegal's most important public health problems, with a mortality rate of 41 deaths per 1,000 live births.
Methods: Between January 2007 and March 2008, 242 neonates with suspected infection were recruited at three neonatal intensive care units in three major tertiary care centers in Dakar, the capital of Senegal. Neonatal infections were confirmed by positive bacterial blood or cerebrospinal fluid culture.
Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections.
View Article and Find Full Text PDFContext: Severe bacterial infections are not considered as a leading cause of death in young children in sub-Saharan Africa. The worldwide emergence of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) could change the paradigm, especially in neonates who are at high risk of developing healthcare-associated infections.
Objective: To evaluate the epidemiology and the burden of ESBL-E bloodstream infections (BSI).
Introduction: Rotavirus is the leading cause of acute severe diarrhea among children under 5 globally and one of the leading causes of death attributable to diarrhea. Among African children hospitalized with diarrhea, 38% of the cases are due to rotavirus. In Senegal, rotavirus deaths are estimated to represent 5.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates pneumococcal carriage and infections in children under 5 in Dakar, revealing high carriage rates (50%) of Streptococcus pneumoniae among participants, with a notable prevalence of specific serotypes.
- It highlights concerns regarding antibiotic susceptibility, showing that 15% of strains have reduced susceptibility to penicillin and 3% to fluoroquinolones, alongside a concerning lethality rate of 42.4% in pneumonia cases.
- Results indicate that while vaccine coverage for different PCV versions is variable, the high rate of carriage and disease reflects the necessity of continued vaccination efforts against prevalent serotypes.
Bacterial meningitis is an important cause of morbidity and mortality in children living in low-resource settings. Pediatric bacterial meningitis cases < 5 years of age were identified through a regional hospital surveillance system for 3 years after introduction of routine immunization with Haemophilus influenzae type b (Hib) conjugate vaccine in Senegal in July 2005. Cases from the national pediatric hospital were also tracked from 2002 to 2008.
View Article and Find Full Text PDFA total of 24 cases of hospitalized, laboratory-confirmed Haemophilus influenzae type b (Hib) meningitis were identified through a regional pediatric bacterial meningitis surveillance system. Each case was matched by age and residence to 4 neighborhood controls. The adjusted vaccine effectiveness for ≥ 2 doses was 95.
View Article and Find Full Text PDFBackground: Senegal introduced routine infant Haemophilus influenzae type b (Hib) conjugate vaccine during 2005.
Methods: We evaluated acute bacterial meningitis surveillance data among children 0 to 59 months of age collected during January 2003 to September 2007 at the major pediatric referral hospital in the Dakar Region of Senegal. Hib vaccine effectiveness was assessed using a case-control design.