Bupropion Showed Neuroprotective Impacts Against Cerebral Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation.

Background: Cerebral ischemia/reperfusion (I/R) injury is the most prevalent form of brain stroke, affecting many patients worldwide. It is believed that oxidative stress and inflammation play major roles in the damage that occurs after the initiation of the disease.

Objectives: Therefore, for the first time, the current study aimed to investigate the neuroprotective effects of bupropion against cerebral I/R damage in a rat model.

Long-term survival for myeloid neoplasms and national health expenditure: A EUROCARE-6 retrospective, population-based study.

Background: EUROCARE, a European population-based cancer project, has shown geographical survival disparities for myeloid neoplasms (MN) suggesting healthcare inequalities. Total National Health Expenditure (TNHE) might influence population-based MN survival. We studied the long-term survival of 15 MN and the TNHE impact on prognosis between European countries.

Learning from Two Decades of Blood Pressure Data: Demography-Specific Patterns Across 75 Million Patient Encounters.

Hypertension is a global health concern with an increasing prevalence, underscoring the need for effective monitoring and analysis of blood pressure (BP) dynamics.We analyzed a substantial BP dataset comprising 75,636,128 records from 2,054,462 unique patients collected between 2000 and 2022 at Emory Healthcare in Georgia, USA, representing a demographically diverse population. We examined and compared population-wide statistics of bivariate changes in systolic BP (SBP) and diastolic BP (DBP) across sex, age, and race/ethnicity.

Fast Actin Disassembly and Fimbrin Mechanosensitivity Support Rapid Turnover in a Model of Clathrin-Mediated Endocytosis.

The actin cytoskeleton is central to force production in numerous cellular processes in eukaryotic cells. During clathrin-mediated endocytosis (CME), a dynamic actin meshwork is required to deform the membrane against high membrane tension or turgor pressure. Previous experimental work from our lab showed that several endocytic proteins, including actin and actin-interacting proteins, turn over several times during the formation of a vesicle during CME in yeast, and their dwell time distributions were reminiscent of gamma distributions with a peak around 1 s.

Disrespect and abuse during childbirth and associated factors among women: a cross-sectional study.

Background: Respectful maternity care is a fundamental right for all women. However, reports of disrespect and abuse are prevalent in various childbirth settings. This study aimed to assess the disrespect and abuse experienced by women during childbirth and associated factors in Comprehensive health centers of Tehran, Iran.

Exploring the neurodegenerative potential of per- and polyfluoroalkyl substances through an adverse outcome pathway network.

While emerging evidence links per- and polyfluoroalkyl substances (PFAS) to neurotoxicity, their potential role in neurodegeneration remains poorly understood. Moreover, existing neurodegeneration-related adverse outcome pathways (AOPs) available on AOP-Wiki have not yet been integrated into a unified network. To address these gaps, this study aims to develop the first neurodegeneration-related AOP network and utilize it to explore the possible contributions of long-chain legacy PFAS to neurodegeneration, specifically concerning Alzheimer's and Parkinson's diseases.

Fabrication of a chitosan-grafted-4‑vinylpyridine/thiol-amine-HZSM-5 nanocomposite via casting method in adsorption of heavy cations from water systems: an evaluation of adsorption mechanism.

This study presents the synthesis of low-silica HZSM-5 zeolite through a hydrothermal process. Subsequently, chitosan-grafted-4‑vinylpyridine/thiol-amine-HZSM-5 nanocomposites were fabricated using casting method for the effective removal of copper (Cu) and zinc (Zn) cations from aqueous systems. The fabricated cast nanocomposites were characterized using XRD, BET, XPS, FESEM, EDX, CHNS, FTIR, and TGA analyses.

The Effectiveness of Functional Clear Aligners for Class II Correction in Growing Patients: A Systematic Review and Meta-Analysis.

Recent developments in aligner materials have enabled them to be a feasible choice for children and adolescents. Aligners offer a treatment modality for Class II correction in growing patients claiming to address a mandibular deficiency. This study aimed to assess the effectiveness of functional aligners in skeletal Class II treatment through a systematic review and meta-analysis of the existing literature.

Tumor microenvironment as a novel therapeutic target for lymphoid leukemias.

Lymphoid leukemias represent a significant global health burden, leading to substantial morbidity and mortality. The intricate interplay between leukemic cells and their surrounding tumor microenvironment (TME) is pivotal in disease initiation, progression, and therapeutic resistance. Comprising a dynamic milieu of stromal, immune, and leukemic cell populations, the TME orchestrates a complex network of signaling pathways and molecular interactions that foster leukemic cell survival and proliferation while evading immune surveillance.

Epidemiology and socioeconomic correlates of gastric cancer in Asia: results from the GLOBOCAN 2020 data and projections from 2020 to 2040.

Gastric cancer represents a major public health burden globally, with a disproportionately high incidence and mortality observed in Asian countries. To analyze the epidemiology of gastric cancer across Asia using data from the GLOBOCAN 2020 database and explore the potential correlations with socioeconomic indicators. The study reported numbers of cases, 5-year prevalence, crude and age-standardized rates of incidence (ASIR) and mortality (ASMR), mortality-to-incidence ratio (MIR), and cumulative risk percentages.

Extracted of polysaccharides from the roots of Eremurus persicus bioss plant / polyvinyl alcohol: Design and characterization of cellular scaffold for cell culture applications.

Biomaterial-based cell scaffolds are one of the interesting cases in tissue engineering. It provides a substrate for repairing and growing different cells which facilitates the healing process of injuries. Therefore, its ingredients must be completely biocompatible and nontoxic to cells.

Plasma treatment can efficiently increase the attachment of pancreatic circulatory tumor cells to the surface.

Pancreatic cancer ranks as the fourth most common cause of cancer-related fatalities globally, with a notably low 5-year relative survival rate. We need to immediately develop fast, dependable, and noninvasive diagnostic techniques that can accurately identify pancreatic cancer at an early stage. The research project created a straightforward but effective method for detecting and increasing the amount of tumor cells that could bind to polystyrene (PS) well plates.

In-situ microscopy and digital image correlation to study the mechanical characteristics of polymer-based materials.

In-situ microscopic methods can help researchers to analyse microstructural changes of materials structures under different conditions (e.g., temperature and pressure) at various length scales.

Global Epidemiology and Socioeconomic Correlates of Salivary Gland Cancer From 2020 to 2040.

Objectives: To report the epidemiology and socioeconomic correlates of salivary gland cancers (SGCs) at global, regional and national levels by age, sex and country.

Methods: Data on the incidence and mortality of SGC for the year 2020 were extracted from the Global Cancer Observatory. The relationships between incidence and mortality rates with the human development index (HDI) and the ratio of current healthcare expenditure to gross domestic product were investigated using bivariate correlation tests.

Ankylosing spondylitis: special considerations and clinical outcomes in surgical management of spinal fractures, case series and analysis of twenty patients.

Ankylosing Spondylitis (AS) is a systemic inflammatory disease that involves the axial skeleton the most. It causes ascending inflammation and, thus, rigidity in the spinal column, from the sacroiliac joint to the cervical region. Spinal column deformities, besides vulnerability to trauma, alter the patients' quality of life and put their neural elements a great risk.

Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases.

Background: Overweight and obesity are a global pandemic, contributing to death and disability-adjusted life-years. Obesity is a major factor in the onset of chronic inflammatory diseases (CIDs). Yet, several knowledge gaps remain: For several CIDs, inconsistent results have been reported, relating to their obesity-imposed risk, data on most rare CIDs remain unavailable, sex differences and racial disparities remain mostly unaddressed.

Reliability and validity of Persian version of the nurses' willingness to engage in palliative care scale.

Introduction: Nurses play an essential role in providing palliative care to improve the quality of life of people with chronic diseases. The Willingness of nurses to engage in this cares is a necessary issue. Therefore, the evaluation of their willingness requires the use of valid, reliable, and suitable tools in the health system of Iran.

Variation of Immunoglobulin M and Immunoglobulin G Serum Levels in Seropositive COVID-19 Patients in Mazandaran, Iran: A Six-Month Investigation.

Background: Forecasting the longevity of patients' immune stability could be the most effective approach to preventing illnesses. This study investigates immunoglobulin M (IgM) serum longevity, immunoglobulin G (IgG), and corresponding risk factors in the first phase seropositive patients in Mazandaran, Iran.

Materials And Methods: This descriptive cross-sectional study aimed to assess IgM and IgG serum levels in a cohort of 184 seropositive patients during six months.

Evaluating the Incidence of Seizures and Its Relationship With Blood Glucose Levels in Tramadol Poisoning Patients Admitted to Imam Reza Hospital in Mashhad (Iran) From 2019 to 2020.

Drug poisoning is the most common type of poisoning in the world. The utilization of tramadol for the management of pain has been identified as a significant contributor to the incidence of poisoning cases. Tramadol poisoning can result in a range of neurological complications, including seizures and a decreased level of consciousness.

The Effect of Heat and Fermentation Treatments of Soybean Meal on Performance, Immune System, Microbial Population, Intestinal Morphology, and PepT1 Gene Expression in Broiler Chickens.

We investigated the effects of replacing raw soybean meal (RSM) with autoclaved soybean meal (ASBM) and fermented soybean meal by Lactobacillus plantarum (FSBMLP) and Bacillus pumilus (FSBMBP) on the performance, microbial population, intestinal morphology, immune system, and PepT1 gene expression in broiler chickens. One-day-old male Ross 308 broiler chicks (n=800) were utilized in a fully randomized design featuring eight treatments and five replicates, and each replicate consisted of 20 chicks. The experimental treatments included: 1) a control group ((RSM)-based diet), 2) a basal diet + ASBM, 3) a basal diet + 2% FSBMLP, 4) basal diet + 4% FSBMLP, 5) basal diet + 6% FSBMLP, 6) basal diet + 2% FSBMBP, 7) basal diet + 4% FSBMBP, and 8) basal diet + 6% FSBMBP.

Effects of BMI on prognosis, disease-free survival and overall survival of breast cancer.

Background: Obese breast cancer patients have worse prognosis than normal weight patients, but the level at which obesity is prognostically unfavorable is unclear. This study aimed to investigate different effects of Body Mass Index (BMI) on prognosis disease-free survival and overall survivor of breast cancer patients.

Method: This retrospective cohort study analyzed the medical records of breast cancer patients who sought treatment at Namazi hospital in Shiraz, Iran between 2014 and 2019.

A review of the anti-bacterial effects exerted by Aronia melanocarpa.

Aronia melanocarpa, a main constituent of black chokeberry, provides a rich source of bioactive molecules including polyphenols, flavonoids, and anthocyanins and has been used for long in traditional medicine due to its various health-promoting and disease-alleviating properties. The aim of our literature survey was to provide an actual update of evidence regarding the antibacterial activities exerted by Aronia melanocarpa and its potential application for the treatment of human bacterial pathogenic including food-borne infections. Our survey revealed that distinct ingredients in Aronia melanocarpa do not only inhibit growth of Gram-positive and to a lesser extent of Gram-negative bacteria, but also biofilm formation that is even more pronounced upon combined application.

The impact of different standing positions on gluteus medius activation and lumbar lordosis in LBP-developers during prolonged standing.

Low back pain (LBP) development has been associated with increased hip muscle co-activation and lumbar lordosis during standing in previously asymptomatic individuals. It is commonly advised to use footrests to relieve LBP. The impact of adjusting arm position on lumbar biomechanics can also be impressive.

Differential antibiosis predisposes mice to Campylobacter jejuni infection: Deeper insights into the impact of the gut microbiota composition in colonization resistance.

Conventional laboratory mice are protected from oral Campylobacter jejuni infection due to colonization resistance (CR) mediated by their host-specific gut microbiota. Here, we used differential effects of distinct antibiotics on gut microbiota composition to identify microbial groups associated with CR against C. jejuni.