Evaluation of hematological markers as prognostic tools in rheumatoid arthritis.

Background: Reducing inflammation is central to the management of RA. However, commonly used markers such as CRP and ESR, along with the DAS-28 score, have shown limitations. Hematologic indices, such as platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and neutrophil-lymphocyte ratio (NLR), show potential as reliable indicators of inflammation in RA.

Quantitative real-time PCR analysis of gut microbiota in rheumatoid arthritis patients compared to healthy controls.

Rheumatoid arthritis (RA) is an autoimmune disorder with synovial inflammation of joints and extra articular manifestations. The results of recent researches consider the relationship between microbiota and the immune system as a double-edged sword. Considering that the relationship between the composition of intestinal microbiota and the immunological and clinical status of the body has been confirmed, it is very important to investigate the effect of each genus and species of bacteria on the state of the immune system.

The Presence of Food Addiction in Patients with Binge Eating Disorder Was Associated with Higher Weight, Poor Body Composition Outcomes, Lower Serum Level of Magnesium and Higher Ferritin 2 Years Post-LSG Surgery.

Background: This study examined the presence of food addiction (FA) in patients with binge eating disorder (BED) 2 years after laparoscopic sleeve gastrectomy (LSG) and explored its association with some minerals, ferritin, weight loss and, body composition outcomes.

Materials And Methods: In this study, 120 patients with BED who had undergone LSG 2 years prior to participation were enrolled. BED was assessed using Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria and presence of FA was assessed using the Yale Food Addiction Scale (YFAS).

Incidence and survival of rare adult solid cancers in Europe (EUROCARE-6): A population-based study.

Background: Rare cancers correspond to approximately 200 clinical entities, which can be grouped into 12 families. Updated data are available for childhood and haematological cancers, ie, for only two of the 12 families of rare cancer. We provide incidence and survival for the remaining ten families of rare adult solid cancers (RAC), across 29 EU Member States and over time.

Isochroman-3,4-dione and Tandem Aerobic Oxidation of 4-Bromoisochroman-3-one in the Highly Regio- and Diastereoselective Diels-Alder Reaction for the Construction of Bridged Polycyclic Lactones.

Herein we report two processes facilitated by diisopropylethylamine (DIPEA) for the synthesis of novel bridged polycyclic molecule analogues to natural products. The use of 4-bromoisochroman-3-one initiated an autoxidation reaction, followed by a Diels-Alder cycloaddition in the presence of electron-deficient dienophiles. Mechanistic studies revealed isochromane-3,4-dione as a key intermediate, which undergoes in situ dienolization/dearomatization followed by a [4 + 2] cycloaddition.

Effect of structural economic transformation on the environment: Insights on transition from goods-based to service-based economies in OECD countries.

Over the past century, the shift from a goods-based to a service-based economy has been profound, especially in developed nations. This paper examines the impact of this transition on CO2 emissions. Using panel data econometric models with fixed and random effects for 23 OECD countries from 1990 to 2022, this study estimates the impact of Cost Disease as an indicator of this transformation on CO2 emissions.

Experiences of Nurses Diagnosed with COVID-19: A Qualitative Study.

Introduction: The COVID-19 disease, which has become a health crisis in the world, has affected various aspects of the personal and professional life of nurses. This study investigated the experiences of nurses diagnosed with COVID-19.

Methods: This was a descriptive qualitative study.

Impaired glucose tolerance and insulin resistance in a prenatally-androgenized rat model of polycystic ovary syndrome in later life.

Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders in reproductive-aged women, is associated with metabolic disturbances. The present study aimed to examine changes in body weight (BW) and glucose and insulin tolerance in a prenatally-androgenized (PNA) rat model of PCOS compared to control with increasing age. Pregnant rats in the experimental group were subcutaneously injected with 5 mg of free testosterone on the 20th day of pregnancy, while the control group received the solvent.

Incidence and prognosis of cutaneous melanoma in European adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results.

Background: Cutaneous melanoma (CM) is rare in adolescents and young adults (AYA, 15-39 years at cancer diagnosis) and studies on CM in AYAs are scarce. Our aim is to update CM incidence and survival in European AYAs and to compare incidence and survival both with other age groups and over time.

Methods: We used the EUROCARE-6 database (108 cancer registries; 29 EU countries), calculating incidence rates (IR) per 100,000 individuals/year in the European population (years of diagnosis: 2006-2013), 5-year relative survival (RS), and 5-year RS conditional to surviving the first year after diagnosis, for the follow-up period 2010-2014 (cases diagnosed in 2006-2013).

Polycystic Ovary Morphology, Subclinical Hypothyroidism, and the Cutoff Value of Thyroid-Stimulating Hormone, a Population-Based Study.

Although numerous studies have explored the link between polycystic ovary syndrome (PCOS) and thyroid dysfunction, the relationship between polycystic ovary morphology (PCOM) and thyroid issues remains unclear. This study aimed to examine the association between PCOM and subclinical hypothyroidism (SCH) as well as the threshold for thyroid-stimulating hormone (TSH). Data were drawn from the Iranian PCOS prevalence study and the Khuzestan PCOS prevalence study.

Efficacy of Phenobarbital, Italept, and Topamax in the Treatment of Neonatal Seizures:A Double-Blinded Cross-Sectional Study of the Iranian Population.

Objectives: Seizures are changes in the electrical activity of the brain. These changes can cause significant or otherwise asymptomatic symptoms. Phenobarbital and phenytoin are known drugs for treating neonatal seizures, but little clinical experience exists using other drugs.

Octenylsuccinated alginate as a delivery agent for encapsulation of bergamot essential oil: Preparation, functional properties and release behavior.

This study evaluate the effect of succinylation of sodium alginate (ALG) by octenyl succinic anhydride (OSA) and its effect on the bergamot essential oil (BEO)-loaded ALG beads. The physico-chemical, antioxidant, antibacterial, and in vitro release properties of BEO-loaded ALG beads were assessed. The presence of BEO in alginate beads was assessd using Fourier transform-infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and differential scanning calorimetry (DSC) experiments.

Health Risks of Asphalt Emission: State-of-the-Art Advances and Research Gaps.

Asphalt-related emissions pose significant health risks due to the release of volatile organic compounds (VOCs) that affect both workers in construction and the general public. Even at low concentrations, certain VOCs are highly toxic, with some of their metabolic byproducts, such as epoxides, known to cause DNA damage, oxidative stress, and other genetic alterations. The health implications are particularly concerning given that these emissions are persistent, and exposure can occur over prolonged periods, especially in urban areas where asphalt is prevalent.

Cardio-Metabolic Risk Profile of Women With Endometriosis: A Population-Based Study.

Aims: Endometriosis (EM) and metabolic disorders are frequent health problems among reproductive-aged women worldwide. Cardio-metabolic risk profile of women with EM is not well understood. We aimed to investigate the cardio-metabolic risk profile of Iranian reproductive-aged women with EM.

Flexible Acetylcholine Neural Probe with a Hydrophobic Laser-Induced Graphene Electrode and a Fluorous-Phase Sensing Membrane.

This work develops the first laser-induced graphene (LIG)-based electrochemical sensor with a superhydrophobic fluorous membrane for a flexible acetylcholine (ACh) sensor. ACh regulates several physiological functions, including synaptic transmission and glandular secretion. The ACh sensing membrane is doped with a fluorophilic cation-exchanger that can selectively measure ACh based on the inherent selectivity of the fluorous phase for hydrophobic ions, such as ACh.

Communication and sexual skills in marital functioning and satisfaction and reduced marital conflicts among Iranian couples: A systematic review.

This study aims to examine the effectiveness of communication and marital (sexual) skills in marital functioning and satisfaction and reduced marital conflicts among Iranian couples. The research literature has been collected from Magiran, SID, Noormags, ISC, and Civilica databases from 2006 to 2021. In the initial search, 104-related articles were extracted and after removing the duplicates, and screening the title and abstract, 34 articles were identified as relevant.

Elucidating the Significance of Zonulin in the Pathogenesis of Chronic Inflammatory Disorders: Emphasis on Intestinal Barrier Function and Tight Junction Regulation.

The intestinal barrier, a critical component of the body's defense system, plays a vital role in maintaining homeostasis by preventing the translocation of harmful substances from the gut lumen into the bloodstream. Disruptions in this barrier, often characterized by increased intestinal permeability, are increasingly recognized as contributors to the development and progression of various Chronic Inflammatory Disorders (CIDs). Zonulin, a key regulator of intestinal Tight Junctions (TJs), has emerged as a pivotal player in this process.

Impact of adiposity indices changes across the lifespan on risk of diabetes in women: trajectory modeling approach.

Aims: The impact of life-course different adiposity indices on diabetes mellitus (DM) is poorly understood. We aimed to do trajectory analysis with repeated measurements of adiposity indices in the development of DM among women across the lifespan.

Methods: This study prospectively investigated the 1,681 population of Tehran Lipid and Glucose Study.

A deep convolutional neural network approach using medical image classification.

The epidemic diseases such as COVID-19 are rapidly spreading all around the world. The diagnosis of epidemic at initial stage is of high importance to provide medical care to and recovery of infected people as well as protecting the uninfected population. In this paper, an automatic COVID-19 detection model using respiratory sound and medical image based on internet of health things (IoHT) is proposed.

Lab-on-a-lollipop (LoL) platform for preventing food-induced toxicity: all-in-one system for saliva sampling and electrochemical detection of vanillin.

Saliva has emerged as a primary biofluid for non-invasive disease diagnostics. Saliva collection involves using kits where individuals stimulate saliva production a chewing device like a straw, then deposit the saliva into a designated collection tube. This process may pose discomfort to patients due to the necessity of producing large volumes of saliva and transferring it to the collection vessel.

Negative pressure wound therapy for extensive soft tissue defects of the lower extremity in a teenager: A case study.

Key Clinical Message: Negative pressure wound therapy (NPWT) aided in the management of complex soft tissue injury in a 14-year-old girl by managing moisture, reducing oedema, and stimulating wound granulation less than 2 months after the accident and prepared the skin for skin grafting, thus successfully saving the limb.

Abstract: This case study describes the use of a tubular bandage encompassing the whole limb to deliver successful NPWT in the treatment and reconstruction of extensive soft tissue damage extending from the right lower extremity to the hip in a 14-year-old female.

Evaluation of the Cytotoxicity of Secondary Bioactive Compounds Produced by in Soil against a Colon Cancer Cell Line.

Colorectal cancer is one of the most serious malignancies affecting humans. In this study, bioactive chemicals extracted from soil were analyzed for their anti-colorectal-cancer and antibacterial properties. A total of 100 soil samples were collected from Kerman-Iran, incubated in SCA media and the antimicrobial properties were tested using the cross-streak method.