Estradiol to progesterone ratio is not a predictor of oocyte maturity at time of ovulation trigger.

Purpose: To evaluate the relationship between progesterone and oocyte maturity rate via estradiol to progesterone ratio (E/P) at the time of ovulatory trigger.

Methods: This is a retrospective cohort study of first autologous IVF cycles from January to December 2018 from a private practice fertility center. Serum estradiol and progesterone levels were measured on the day of ovulatory trigger.

Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report.

Objective: To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2.

Design: Case report.

Setting: Private in vitro fertilization clinic.

Euploid rates among oocyte donors: is there an optimal age for donation?

Purpose: To examine cycle blastocyst euploid rates among age subgroups of oocyte donors.

Methods: Retrospective cohort analysis of ova donation in vitro fertilization cycles (OD-IVF) for which trophectoderm biopsy for preimplantation genetic testing for aneuploidy (PGT-A) by array comparative genomic hybridization (aCGH) or next generation gene sequencing (NGS) was employed between January 2015 and December 2018 in a single high-volume fertility center.

Results: Compared to oocyte donors age 26-30, oocyte donors age ≤ 25 had similar cycle blastocyst euploid rates (80 [66.

Current status of spent embryo media research for preimplantation genetic testing.

In recent years, a growing body of literature has emerged investigating the clinical utility of spent embryo media (SEM) for preimplantation genetic testing for aneuploidy (PGT-A) (Hammond et al. in Fertil Steril. 107(1):220-8, 2017; Xu et al.

Transfer of embryos with segmental mosaicism is associated with a significant reduction in live-birth rate.

Objective: To evaluate the impact of segmental mosaicism on pregnancy outcomes from the transfer of embryos previously designated as euploid.

Design: Retrospective cohort analysis.

Setting: Single, private, high-volume fertility center.

Earlier day of blastocyst development is predictive of embryonic euploidy across all ages: essential data for physician decision-making and counseling patients.

Purpose: The purpose of this study is to evaluate whether day of blastocyst development is associated with embryo chromosomal status as determined by high-density oligonucleotide microarray comparative genomic hybridization (aCGH).

Methods: This is a retrospective cohort analysis, including women who underwent in vitro fertilization (IVF) with trophectoderm biopsy at a single private fertility center from January 2014 to December 2014. Repeat cycles were excluded.

Cost-Benefit Analysis of Hysteroscopic Polypectomy Before Controlled Ovarian Hyperstimulation and Intrauterine Insemination in Infertile Women.

Objective: To examine the cost benefit of performing hysteroscopic polypectomy (HP) in infertile women with endometrial polyp(s) before controlled ovarian hyperstimulation with intrauterine insemination (COH/IUI).

Study Design: Decision analytic model comparing costs and clinical outcomes.

Results: HP and COH/IUI costs ranged from $537–$12,530 and $800–$7,600, respectively.

Attributes That Fellowship Directors Value in the Selection of Reproductive Endocrinology and Infertility Fellows.

OBJECTIVE: To investigate which attributes of reproductive endocrinology and infertility (REI) fellowship applicants are most valued by fellowship program directors during the match process. STUDY DESIGN: An electronic survey was administered to determine characteristics most favored by program directors in the selection of REI fellows. A 5-point Likert scale was utilized to rank characteristics, with 1 being "most important" and 5 being" least important.

Proof of concept: preimplantation genetic screening without embryo biopsy through analysis of cell-free DNA in spent embryo culture media.

Objective: To assess whether preimplantation genetic screening (PGS) is possible by testing for free embryonic DNA in spent IVF media from embryos undergoing trophectoderm biopsy.

Design: Prospective cohort analysis.

Setting: Academic fertility center.

Logarithmic curves depicting initial level and rise of serum beta human chorionic gonadotropin and live delivery outcomes with in vitro fertilization: an analysis of 6021 pregnancies.

Objective: To correlate the live delivery rate with the initial level and rise of serum beta-hCG.

Design: Retrospective cohort analysis.

Setting: Large private academic center for assisted reproductive technologies and infertility.

Embryonic synergism may reduce pregnancy loss: a multivariate regression analysis.

Objective: To evaluate clinical and assisted reproductive technology (ART) cycle variables related to spontaneous embryo reduction.

Design: Observational retrospective cohort study.

Setting: Private ART center.

Immunohistochemical expression of endometrial L-selectin ligand is higher in donor egg recipients with embryonic implantation.

Objective: To correlate L-selectin ligand (LSL) expression in human endometrium with embryonic implantation.

Design: Retrospective cohort analysis.

Setting: University-based fertility center.

Oocyte and ovarian tissue cryopreservation: indications, techniques, and applications.

With recent advances in cryobiology, cryopreservation of the oocyte and ovarian tissue is rapidly becoming an important service provided by medical centers throughout the world. The general indication for oocyte or ovarian tissue cryopreservation is to retain future fertility potential for women who face the possibility of premature or imminent ovarian failure resulting from treatments for various disease states including cancer. Considering limitations imposed by age, lack of a partner, or sufficient time to undergo embryo cryopreservation, these patients have few options if they desire preservation of their fertility.

Ultrasound-guided trial transfer may be beneficial in preparation for an IVF cycle.

Background: The objective of this study is to determine if ultrasound-guided trial transfer (UTT) in the office in preparation for an IVF cycle can be utilized as an alternative and/or adjunct to ultrasound-guided embryo transfer (UGET).

Methods: Patients planning to undergo an IVF cycle at an academic centre were included. Each patient underwent an UTT in the office by the same practitioner.

Ovarian tissue cryopreservation: benefits and risks.

An increasing number of women have been subjected to cytotoxic chemoradiotherapy for various malignant and nonmalignant diseases. Women who face the possibility of premature or imminent ovarian failure caused by cytotoxic therapy may retain their fertility potential with ovarian tissue cryopreservation. Until recently, this technique could only be performed in a few highly specialized institutions.

Ultrasound-guided embryo transfer and the accuracy of trial embryo transfer.

Background: Studies have suggested that ultrasound-guided embryo transfer (UG-ET) may improve the outcome in IVF; however, several factors may account for the improvement in pregnancy rate. This study examines the use of ultrasound to determine the accuracy of trial transfer (TT) in preparation for ET.

Methods: Sixty-seven consecutive patients prospectively underwent UG-ET over a 2 month period.