Publications by authors named "Mourtala Mohamed Assao Neino"
Coronavirus disease has disrupted tuberculosis services globally. Data from 33 centers in 16 countries on 5 continents showed that attendance at tuberculosis centers was lower during the first 4 months of the pandemic in 2020 than for the same period in 2019. Resources are needed to ensure tuberculosis care continuity during the pandemic.
View Article and Find Full Text PDFHigh rifampicin-resistant TB cure rates and prevention of severe ototoxicity after replacing the injectable by linezolid in early stage of hearing loss.
Eur Respir J
January 2021
The short treatment regimen (STR) achieves a >80% cure in rifampicin-resistant tuberculosis (RR-TB) patients. However, ototoxicity induced by the injectable is a concern. This is the first study to evaluate the replacement of injectables by linezolid in patients with audiometry abnormalities at baseline or during the treatment.
View Article and Find Full Text PDFBackground: In Niger, the Shorter Treatment Regimen (STR) has been implemented nationwide for rifampicin resistant tuberculosis (RR-TB), since 2008. No previous publication has shown the results from countrywide programmatic implementation using few exclusion criteria, nor exhaustively assessed the effect of initial resistance to companion drugs on outcomes.
Methods: The National Tuberculosis Programme and the Damien Foundation conducted a retrospective observational study to evaluate the management of RR-TB from 2008 to 2016.
Article Synopsis
- - The study compared two WHO-recommended treatments for rifampin- or multidrug-resistant tuberculosis: a shorter regimen lasting 9-12 months and a longer individualized regimen of at least 20 months, using data from various observational studies.
- - Results showed that the shorter regimen had a higher overall treatment success rate (80.0% vs. 75.3%) and significantly less patient loss to follow-up, though it had a slightly higher risk of treatment failure or relapse, especially in patients with resistance to certain medications.
- - The findings suggest that while the shorter regimen is more effective in maintaining patient engagement, there is a need for better drug susceptibility testing to ensure appropriate treatment, particularly for those with medication resistance. *